Effects of Convalescent Plasma Therapy on TNF-α and IFN-γ in Randomized COVID-19 patients at Haji Surabaya General Hospital

Introduction: The preferred treatment for COVID-19 cases is Convalescent Plasma. In COVID-19 patients, cytokine storms are caused by high levels of cytokines including: Inflammatory cytokines such as (IL-10, IL-12, IL-27, IL-21, TNF-α and IFN-γ, IL-2, and IL-6), are triggered by T cell responses. The goal of this research is to determine Does administration of convalescent plasma affect the TNF-α and IFN-γ cases of COVID-19 sufferers. Materials and methods: The experimental research method uses (a post-test only control group design). The study material in the form of serum from the blood of COVID-19 patients as many as 38 samples selected randomly with details of COVID-19 patients as many as 19 samples were not given convalescent plasma treatment and 19 samples of COVID-19 patients receiving convalescent plasma therapy. Results: This study showed that there was no effect on TNF-α levels before and after convalescent plasma administration (P> 0.05), while IFN-γ levels showed an effect between before and after convalescent plasma administration (P< 0.05). Conclusion: Although in this study there were differences in the results of statistical analysis of TNF-α and IFN-γ levels in convalescent plasma treatment of COVID-19 patients, this study proved to be able to improve the clinical condition of COVID-19 cases.