TY - JOUR
T1 - Effects of centella asiatica extract on pro-inflammatory cytokines (Tnf-α) in severe early childhood caries and caries free
AU - Rachmadi, Priyawan
AU - Luthfi, Muhammad
AU - Oki, Aqsa Sjuhada
AU - Mar, Mieke Sylvia
AU - Rifai, Muhaimin
N1 - Publisher Copyright:
© 2020, Agri. Bio. Publishers. All rights reserved.
PY - 2020/4
Y1 - 2020/4
N2 - Dental caries is a chronic, multifactorial disease that begins with a microbiological shift in complex biofilms (dental plaque) that is influenced by consumption of sugar, salivary flow, and behaviour. The present investigation was undertaken to analyze the expression of pro-inflammatory cytokines TNF-α on salivary neutrophil surfaces using flow cytometer. Extra Centella asiatica reduced pro-inflammatory cytokines TNF-α on the neutrophil surface of salivary free caries at 0 µg/ml (24.04±0.70), 12.5 µg/ml (21.88±1, 48), 25 µg/ml (20.56±0.95), 50 µg/ml (19.28±1.32), 100 µg/ml (18.07±1.17), 200 µg/ml (17.28±0.84), while in S-ECC at 0 (35.95±3.50), 12.5 (28.88±1.32), 25 (27.82±1.28), 50 (26.46±2.95) and 100 (23.46±1.42). C. asiatica decreased pro-inflammatory cytokines TNF-α produced by salivary neutrophils.
AB - Dental caries is a chronic, multifactorial disease that begins with a microbiological shift in complex biofilms (dental plaque) that is influenced by consumption of sugar, salivary flow, and behaviour. The present investigation was undertaken to analyze the expression of pro-inflammatory cytokines TNF-α on salivary neutrophil surfaces using flow cytometer. Extra Centella asiatica reduced pro-inflammatory cytokines TNF-α on the neutrophil surface of salivary free caries at 0 µg/ml (24.04±0.70), 12.5 µg/ml (21.88±1, 48), 25 µg/ml (20.56±0.95), 50 µg/ml (19.28±1.32), 100 µg/ml (18.07±1.17), 200 µg/ml (17.28±0.84), while in S-ECC at 0 (35.95±3.50), 12.5 (28.88±1.32), 25 (27.82±1.28), 50 (26.46±2.95) and 100 (23.46±1.42). C. asiatica decreased pro-inflammatory cytokines TNF-α produced by salivary neutrophils.
KW - Neutrophil cells
KW - Severe early childhood caries
KW - TNF-α pro-inflammatory cytokines
UR - http://www.scopus.com/inward/record.url?scp=85086170158&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:85086170158
SN - 0970-0153
VL - 36
SP - 220
EP - 226
JO - Annals of Biology
JF - Annals of Biology
IS - 2
ER -