Effectiveness of the Aedes aegypti Mosquito Vector Control Program in Southeast Asia – A Systematic Review

Sulistiawati, Miranda Jemyma Mas’ulun, Anggita Kanza Ramadhany, Afiel Nadhifa Hanafie, Rani Fitri Alfiani, Sarah Evita Husnah, Agnes Ilene Suprapto Puteri, Anisa Novia Mahestari

Research output: Contribution to journalReview articlepeer-review


Background: Dengue is still a major vector-borne disease problem in the world. It is caused by infection with the Dengue virus, which can be spread through a vector in the form of the Aedes aegypti mosquito. One of the ways to reduce the incidence of dengue infection is by controlling vectors. Aim: This study aims to analyze the effectiveness of vector control of the Aedes aegypti mosquito on the dengue incidence in Southeast Asia. Methods and findings: This study was a systematic review that examines articles with experimental research designs and cluster randomized controlled trials. The scope of this research area is limited to Southeast Asian countries during 2012-2021. There are 333 articles obtained from two sources: PubMed and ScienceDirect, by using certain . Furthermore, articles were selected based on inclusion and exclusion criteria, so that 31 articles were obtained. A total of 6 articles that met the inclusion criteria were then selected for further analysis. Three journals that discussed the output in the form of the Larva Density Index (LDI) showed a decrease with significant results. Two journals that discussed biological control (Bacillus thuringiensis israelensis) got significant results in decreasing Pupal Density (PD). The two journals on chemical control (permethrin) that discussed the outcome of the presence or absence of IgG seroconversion show insignificant results. Conclusion: All control methods are considered effective. However, among the three vector control methods studied, the control with Bacillus thuringiensis israelensis is the most effective method.

Original languageEnglish
Pages (from-to)969-975
Number of pages7
JournalPharmacognosy Journal
Issue number5
Publication statusPublished - 2023


  • Aedes aegypti
  • Dengue
  • Dengue Control Program
  • Tropical Disease
  • human and health
  • medicine


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