Effectiveness of convalescent plasma therapy for COVID-19 patients infected with variants of concerns

Eighty Mardiyan Kurniawati, Innas Safira Putri, Deandra Maharani Widiatmaja, Venansya Maulina Praba, Visuddho, Faida Ufaira Prameswari, Marsha Zahrani, Felix Nugraha Putra, David Nugraha, Antonio Ayrton Widiastara

Research output: Contribution to journalReview articlepeer-review

Abstract

COVID-19 cases in Indonesia seemed to be increasing by each passing day at the time of writing this review, more positive cases discovered than the recovered ones. With the highest rank within all ASEAN countries, and also a home of many variants of COVID-19, Indonesia had become a break off destination to others. Along with the problem associated with the pandemic, which all people had to face, the purpose of this review is to elaborate the use of convalescent plasma therapy on treatment against COVID-19, especially its different variants. We overview the evidence that we obtained from several databases using specific keywords. A large amount of evidence points out that the convalescent plasma therapy has shown a promising outcome against COVID-19 infection, as it did for infectious diseases. Although in COVID-19 variants of concern, convalescent plasma therapy showed a reduction in neutralization ∼ 3-fold against P.1, and 7-13 folds against B.1.351 variant, it still can be used as a treatment for COVID-19 and its variants.

Original languageEnglish
Pages (from-to)535-545
Number of pages11
JournalAnaesthesia, Pain and Intensive Care
Volume26
Issue number4
DOIs
Publication statusPublished - Aug 2022

Keywords

  • COVID-19, Variants of Concern
  • Convalescent plasma therapy

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