Effect of White Rice Substitution with Sorghum Rice on Beta Cell Function and Insulin Resistance in Prediabetes

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Abstract

Background: Decrease in the function of beta cells and insulin resistance (IR) is found in prediabetes. Sorghum rice is a staple food substitute for white rice which has low GI and GL, high fiber, rich in polyphenols which can improve IR and beta cell function. This study aims to analyze the effect of sorghum rice on beta cell function and IR in prediabetes. Methods: An open experimental study with a preposttest design on prediabetes patients at Bojonegoro Police Polyclinic and Bojonegoro Bhayangkara Hospital. Treatment is standard lifestyle intervention plus the substitution of white rice with sorghum rice for 7 days compared to a standard lifestyle. IR examination using the HOMA-IR formula and beta cell function with HOMA-B. Results: Standard lifestyle intervention plus diet substitution with sorghum rice for 7 days in prediabetes patients resulted in FBG of 7.5 mg/dL (p=0.014) and an increase in HOMA-B of 85.3 % (p= 0.019), while the decrease in HOMA-IR was not significant (p=0.060). When compared with the standard lifestyle, this intervention was better but not statistically significant (p>0.05). Conclusion: Standard lifestyle intervention plus diet substitution with sorghum rice for 7 days influences FBG and beta cell function in prediabetic patients but not on IR.

Original languageEnglish
Pages (from-to)S112-S120
JournalGaceta Medica de Caracas
Volume131
DOIs
Publication statusPublished - Apr 2023

Keywords

  • Prediabetes
  • beta cell function
  • insulin resistance
  • rice sorghum

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