TY - JOUR
T1 - Effect of vitamin D during orthodontic tooth movement on receptor activator of nuclear factor Kappa-B ligand expression and osteoclast number in pregnant wistar rat (Rattus novergicus)
AU - Narmada, Ida Bagus
AU - Husodo, Kinanthi Rizka Dewi
AU - Ardani, I. Gusti Aju Wahju
AU - Rahmawati, Dwi
AU - Nugraha, Alexander Patera
AU - Iskandar, Regina Purnama Dewi
N1 - Publisher Copyright:
© Journal of Krishna Institute of Medical Sciences University.
PY - 2019
Y1 - 2019
N2 - Background: Female patients have the possibility to become pregnant during orthodontic treatment. Vitamin D usually consumed by pregnant women. Estrogen and Vitamin D could affect bone metabolism. Aim and Objectives: The aim of this study was to analyze the effect of vitamin D during orthodontic movement in pregnant rats by Receptor Activator of Nuclear Factor Kappa-B Ligand (RANKL) expression and osteoclast number. Material and Methods: The experimental observational analytic study with post-test only control group design and simple random sampling method was conducted. 24-healthy-female Wistar rats were divided into 4 groups; K1: pregnant rats with orthodontic tooth movement and vitamin D on Day 7; K2: pregnant rats with orthodontic tooth movement and vitamin D on Day 14; K3: pregnant rats with orthodontic tooth movement without vitamin D on Day 7 and; K4: pregnant rats with orthodontic tooth movement without vitamin D on Day 14. Nickle-Titanium coil spring with 10 g/mm2 force was placed between the incisors and the maxillary molars. The RANKL expression and osteoclasts number were analyzed using Analysis of Variance (ANOVA) (p<0.05). Results: The highest osteoclasts number (8.494 ± 1.194), and RANKLexpression (7.967 ± 2.185) found in K1 group with significant between groups (p<0.05).Conclusions: Vitamin D increase osteoclast number and RANKL expression during orthodontic tooth movement in pregnant rats.
AB - Background: Female patients have the possibility to become pregnant during orthodontic treatment. Vitamin D usually consumed by pregnant women. Estrogen and Vitamin D could affect bone metabolism. Aim and Objectives: The aim of this study was to analyze the effect of vitamin D during orthodontic movement in pregnant rats by Receptor Activator of Nuclear Factor Kappa-B Ligand (RANKL) expression and osteoclast number. Material and Methods: The experimental observational analytic study with post-test only control group design and simple random sampling method was conducted. 24-healthy-female Wistar rats were divided into 4 groups; K1: pregnant rats with orthodontic tooth movement and vitamin D on Day 7; K2: pregnant rats with orthodontic tooth movement and vitamin D on Day 14; K3: pregnant rats with orthodontic tooth movement without vitamin D on Day 7 and; K4: pregnant rats with orthodontic tooth movement without vitamin D on Day 14. Nickle-Titanium coil spring with 10 g/mm2 force was placed between the incisors and the maxillary molars. The RANKL expression and osteoclasts number were analyzed using Analysis of Variance (ANOVA) (p<0.05). Results: The highest osteoclasts number (8.494 ± 1.194), and RANKLexpression (7.967 ± 2.185) found in K1 group with significant between groups (p<0.05).Conclusions: Vitamin D increase osteoclast number and RANKL expression during orthodontic tooth movement in pregnant rats.
KW - Orthodontic tooth movement
KW - Osteoclast
KW - Pregnant
KW - Receptor activator of nuclear factor kappa-B Ligand
KW - Vitamin D
UR - http://www.scopus.com/inward/record.url?scp=85062527961&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:85062527961
SN - 2231-4261
VL - 8
SP - 37
EP - 42
JO - Journal of Krishna Institute of Medical Sciences University
JF - Journal of Krishna Institute of Medical Sciences University
IS - 1
ER -