Effect of Sticophus hermanii extract on fasting blood glucose and skeletal muscle glut4 on type 2 diabetes mellitus rats model

The purpose of this study was to prove that Sticophus hermanii (SH) extract can lower blood glucose levels and increase skeletal muscle GLUT4 levels in Type 2 Diabetes Mellitus (T2DM) rats model. This research is a laboratory experimental study, with complete randomized design. Thirty rats (Wistar rats) were randomly divided into five groups, a normal control group and four T2DM rat groups by intra peritoneal STZ 50 mg/kg BW. The four T2DM rat groups divided into control positif group (without giving anything), given metformin 100 mg (first-line drugs T2DM), SH 8.5 mg and 17mg/kg BW, respectively, by gastric intubations every day during 2 weeks. After 2 weeks the rats sacrificed to measure blood glucose level with stikNesco multicheck and skeletal muscle GLUT4 level with elisa method. The results of this study were 1) blood glucose levels of T2DM rats decreased significantly, with the giving of SH 8.5 mg/kg body weight and 17 mg/kg body weight and gave the same effect with metformin 100 mg/kg body weight, 2) Skeletal muscle Glut 4 of T2DM rats increased significantly, with the giving of SH 8.5 mg/kg body weight and 17 mg/kg body weight and giving effect equal to metformin 100 mg/kg body weight. The conclusion was administration of SH extract at dosage 8.5 mg/kg body weight or 17 mg/kg body weight in T2DM rats statistically gives the same effect with metformin 100 mg/kg body weight, but it seems that dosing 8.5 mg/kg body weight gives better effect.