TY - JOUR
T1 - Effect of resveratrol dimers and tetramers isolated from vitaceous and dipterocarpaceous plants on human SIRT1 enzyme activity
AU - Hikita, Kiyomi
AU - Seto, Norikazu
AU - Takahashi, Yusuke
AU - Nishigaki, Ayako
AU - Suzuki, Yuya
AU - Murata, Tomiyasu
AU - Loisruangsin, Arthorn
AU - Aminah, Nanik Siti
AU - Takaya, Yoshiaki
AU - Niwa, Masatake
AU - Kaneda, Norio
N1 - Publisher Copyright:
© 2018 Natural Product Incorporation.
PY - 2018/11
Y1 - 2018/11
N2 - SIRT1 is a mammalian ortholog of the yeast enzyme Sir2, which is an NAD+-dependent deacetylase of histones, p53, FOXO, NF-κB, PGC-1α, and other transcription factors. The Sir2 protein is reported as a longevity protein in yeast. Resveratrol, a polyphenol isolated from various types of plant families, particularly the Vitaceae family, is a known naturally occurring SIRT1 activator. In this study, we evaluated the effects of four types of resveratrol dimers and four types of tetramers isolated from vitaceous plants, and one type of resveratrol tetramer isolated from a dipterocarpaceous plant on purified human SIRT1 enzyme activity. Of the resveratrol dimers examined, (+)-ϵ-viniferin and pallidol exhibited no effect on SIRT1 enzyme activity, whereas (+)-ampelopsin B and (-)-ampelopsin F showed inhibitory activity on SIRT1. However, all the resveratrol tetramers examined, i.e., (+)-vitisin A, (-)-vitisin B, (+)-hopeaphenol, (-)-hopeaphenol, and (-)-isohopeaphenol markedly inhibited the human SIRT1 enzyme activity. (+)-Hopeaphenol exhibited the most potent inhibitory activity, which was comparable with that exhibited by a known SIRT1 inhibitor suramin. Since SIRT1 inhibitors reportedly possess anticancer activity, (+)-hopeaphenol and other resveratrol oligomers can be used as a seed compound for anticancer drugs.
AB - SIRT1 is a mammalian ortholog of the yeast enzyme Sir2, which is an NAD+-dependent deacetylase of histones, p53, FOXO, NF-κB, PGC-1α, and other transcription factors. The Sir2 protein is reported as a longevity protein in yeast. Resveratrol, a polyphenol isolated from various types of plant families, particularly the Vitaceae family, is a known naturally occurring SIRT1 activator. In this study, we evaluated the effects of four types of resveratrol dimers and four types of tetramers isolated from vitaceous plants, and one type of resveratrol tetramer isolated from a dipterocarpaceous plant on purified human SIRT1 enzyme activity. Of the resveratrol dimers examined, (+)-ϵ-viniferin and pallidol exhibited no effect on SIRT1 enzyme activity, whereas (+)-ampelopsin B and (-)-ampelopsin F showed inhibitory activity on SIRT1. However, all the resveratrol tetramers examined, i.e., (+)-vitisin A, (-)-vitisin B, (+)-hopeaphenol, (-)-hopeaphenol, and (-)-isohopeaphenol markedly inhibited the human SIRT1 enzyme activity. (+)-Hopeaphenol exhibited the most potent inhibitory activity, which was comparable with that exhibited by a known SIRT1 inhibitor suramin. Since SIRT1 inhibitors reportedly possess anticancer activity, (+)-hopeaphenol and other resveratrol oligomers can be used as a seed compound for anticancer drugs.
KW - (+)-Hopeaphenol
KW - Resveratrol oligomer
KW - SIRT1 inhibitor
KW - Sirtuin
UR - http://www.scopus.com/inward/record.url?scp=85057868266&partnerID=8YFLogxK
U2 - 10.1177/1934578x1801301130
DO - 10.1177/1934578x1801301130
M3 - Article
AN - SCOPUS:85057868266
SN - 1934-578X
VL - 13
SP - 1531
EP - 1534
JO - Natural Product Communications
JF - Natural Product Communications
IS - 11
ER -