Abstract
Objective: To evaluate the effect of Muntingia calabura L. leaf extract on the blood glucose level and weight of alloxan-induced diabetic mice. Methods: The mice were injected using 150mg/kg of alloxan intraperitoneally to induce diabetes. Blood glucose level was tested before alloxan injection and 5 days after injection to confirm diabetes development. M. calabura leaf extract with 100 and 300 mg/kg and 600 µg/kg of glibenclamide was given orally for 14 days. Results: The statistical results showed a significant decrease in blood glucose level, especially on day-7 and day-14 in the M. calabura leaf extract treatment group and glibenclamide treatment group compared to the model control group. There was an increase of weight on day-7 and day-14 in the M. calabura leaf extract group and a significant decrease in weight on day-7 in the glibenclamide group compared to the model control group. Conclusion: M. calabura leaf extract had a significant antidiabetic effect that can normalize the weight of alloxan-induced diabetic mice.
| Original language | English |
|---|---|
| Pages (from-to) | 1450-1455 |
| Number of pages | 6 |
| Journal | Pharmacognosy Journal |
| Volume | 13 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - Dec 2021 |
Keywords
- Alloxan
- Diabetes
- Mice
- Muntingia calabura leaf
