Effect of Muntingia calabura L. Leaf Extract on blood glucose levels and body weight of alloxan-induced diabetic mice

Tridiganita Intan Solikhah, Gahastanira Permata Solikhah

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)

Abstract

Objective: To evaluate the effect of Muntingia calabura L. leaf extract on the blood glucose level and weight of alloxan-induced diabetic mice. Methods: The mice were injected using 150mg/kg of alloxan intraperitoneally to induce diabetes. Blood glucose level was tested before alloxan injection and 5 days after injection to confirm diabetes development. M. calabura leaf extract with 100 and 300 mg/kg and 600 µg/kg of glibenclamide was given orally for 14 days. Results: The statistical results showed a significant decrease in blood glucose level, especially on day-7 and day-14 in the M. calabura leaf extract treatment group and glibenclamide treatment group compared to the model control group. There was an increase of weight on day-7 and day-14 in the M. calabura leaf extract group and a significant decrease in weight on day-7 in the glibenclamide group compared to the model control group. Conclusion: M. calabura leaf extract had a significant antidiabetic effect that can normalize the weight of alloxan-induced diabetic mice.

Original languageEnglish
Pages (from-to)1450-1455
Number of pages6
JournalPharmacognosy Journal
Volume13
Issue number6
DOIs
Publication statusPublished - Dec 2021

Keywords

  • Alloxan
  • Diabetes
  • Mice
  • Muntingia calabura leaf

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