Effect of Methadone on the Brain Activity in Close Eyes Condition

Arjon Turnip, Dwi Esti Kusumandari, Siti Aminah Sobana, Arifah Nur Istiqomah, Teddy Hidayat, Shelly Iskandar, Yumna Nabila, Ririn Amrina, Putri Madona

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

1 Citation (Scopus)


Drug abuse in various parts of the world is increasingly widespread. Therefore, a drug addict should immediately stop and must be recovered. To overcome the symptoms of addiction, the use of methadone as a synthetic drug to replace opioid type drugs is recommended. In this paper, an experiment with rehabilitation patients to identify the effect of the drugs on the brain activity in the frontal, central, temporal, and occipital lobes is proposed. The EEG data collection is performed using 18 channel electrodes, namely central: C3, C4; frontal: Fp1, Fp2, F3, F2, F4, F7, F8; occipital: P3, Pz, P4, O1, O2; and temporal: T3, T4, T5, T6. In the brain signals record, subjects were asked to comfortably sit in a chair. The recording was done in three sessions: 5 min before drinking methadone, 10 and 60 min after drinking the methadone, respectively. To reduce background noise and artifacts removal, bandpass filter (0.5–50 Hz) and wavelet method were applied, respectively. From this experiment, it was found that a decrease in amplitude after methadone intake for average in four lobes is obtained. The result indicates that the use of methadone is highly effected on the entire brainwave activity which indicates a decrease in the level of desire to do activities.

Original languageEnglish
Title of host publicationCyber Physical, Computer and Automation System - A Study of New Technologies
EditorsEndra Joelianto, Arjon Turnip, Augie Widyotriatmo
PublisherSpringer Science and Business Media Deutschland GmbH
Number of pages12
ISBN (Print)9789813340619
Publication statusPublished - 2021
Externally publishedYes
EventInternational Conference on Cyber Physical, Computer and Automation Systems, CPCAS 2019 - Bali, Indonesia
Duration: 13 Nov 201915 Nov 2019

Publication series

NameAdvances in Intelligent Systems and Computing
Volume1291 AISC
ISSN (Print)2194-5357
ISSN (Electronic)2194-5365


ConferenceInternational Conference on Cyber Physical, Computer and Automation Systems, CPCAS 2019


  • Brain activity
  • EEG-P300
  • Frontal lobe
  • Methadone
  • Visual stimuli


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