Effect of Lycopene on Prostate Specific Antigen (PSA) and Stimulator Cell Growth Factor in Non-Metastatic Prostate Cancer Patients: A Systematic Review and Meta-Analysis

Prostate cancer (PCa) is the third leading cause of death in the world. Dietary extract lycopene from tomato extract has been identified as one possible candidate for reducing risk of PCa. Some research findings are still equivocal. The aims of study to evaluate effects of dietary lycopene from tomato extract compare to the control on PSA level, IGF-1, and IGF BP-3 by conducting a systematic review and meta-analysis. Method for this research, we searched Cochrane Database, PUBMED, MEDLINE. All randomised controlled trials (RCTs) of lycopene from tomato extract for in prostate cancer patient were included, without language or date restrictions. Ten RCT’s compared extract lycopene with control, total of 427 patients were analyzed. The mean number of PSA [MD] -0.35, 95% [CI] -0.64 to -0.07 (P 0.02), IGF-1 [MD] -2.01, 95% [CI] -3.33 to -0.69 (P 0.003), IGF BP-3 [MD] 2.70, 95% [CI] 0.96 to 4.44 (P 0.002). This result identified, extract lycopene had a significant difference in PSA level, IGF-1, and IGF BP-3 compared to control.