Effect of hyperbaric oxygen therapy on icam-1 expression in artery spiralis of pregnant rattus norvegicus infected by tachyzoite from toxoplasma gondii

Introduction: Toxoplasma gondii infection increases the production of Th1 cytokines that can cause fetal rejection. This study aims to determine the effect of hyperbaric oxygen therapy (HBOT) in the artery spiralis expressions of ICAM-1 in pregnant Rattus norvegicus infected by tachyzoite of Toxoplasma gondii. Material and Method: The rats were divided into four groups randomly. Determination of ICAM-1 expressions was performed on day-5 after HBOT and measured through Immunohistochemistry examination. Result: There was no significant difference in ICAM-1 expression among all groups (A and B [p <0.626], A and C [p <0.450], A and D [p <0.770], B and C (p <0.792), B and D [p <0.812], C and D [p <0.600]). However, the results showed that HBOT could not reduce ICAM-1 expression (6.4, 5.73, 5.4, 6.03, the mean ICAM-1 expression in HBO2 treatment group was the highest). Conclusion: This study concluded that HBOT could not reduce the expressions of ICAM-1 in artery spiralis with no significant difference among all groups.