Glutamine known as one of conditional essential amino acid play a role in several mechanism to support health of organism. Many researchs reported the use of glutamine to improve signalling pathways well as form and function in intestine. This research aims to study the effect of oral glutamine administration on the spectrin, clathrin expression and STAT-3 signaling protein in the repair of microvilli of intestinal epithelial mucosa damaged on malnutrition rats (Rattus norvegicus). Four groups of rats were used: control (group I), malnutrition (group II), normal+glutamine (group III) and malnutrition+glutamine (group IV). Group II and IV received “ a karak diet” for 15 days, Group III and IV then received glutamine supplement dose of 500 mg/kg/BW for next 15 days. Then it was sacrified to collect their intestinal ileum to be used for immunohistochemistry techniques using spectrin, clathrin and STAT-3 antibodies. Glutamine administration could increase spectrin, clathrin and STAT-3 expression on intestinal ileum on malnutrition rats. It was also showed that glutamine could repair intestinal ileum microvilli and support the improvement structure. This research could provide new insights in understanding the potency of glutamine on malnutrition rats have possibility to develope on the clinical use of glutamine in the management of malnutrition in humans.

Original languageEnglish
Pages (from-to)325-329
Number of pages5
JournalInternational Journal of PharmTech Research
Issue number3
Publication statusPublished - 14 Jul 2015


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