Abstract
Objective: This study aims to evaluate the expression of the proinflammatory cytokine interleukin-1 (IL-1) and TGF-β in the bone remodeling process during orthodontic treatment due to the influence of alcohol intake Material and Method: Twenty male Wistar rats were randomly assigned to two groups: control group (CG) = non-exposed to ethanol intake (n = 10), and Experimental Group (EG) = alcohol intake (n = 10). Ethanol administration was carried out for 0 days and 14. days according to the subgroups. Measurement of tooth movement in experimental animals was carried out, then killed, then preparations were made and Immunohistochemical (IHC) examination to calculate IL-1 and TGF-β expression, then data analysis using independent t test. Results: Statistical test results with independent sample t-test showed that there was a significant difference in IL-1 and TGF-β expression between the control group and the treatment group with a p value <0.05. Conclusion: There is an effect of ethanol on IL-1 and TGF-β expression during the alveolar bone remodeling process in orthodontic tooth movement.
| Original language | English |
|---|---|
| Pages (from-to) | 95-99 |
| Number of pages | 5 |
| Journal | Journal of Dentomaxillofacial Science |
| Volume | 9 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 2024 |
Keywords
- Alveolar bone remodeling
- Ethanol
- IL-1
- Orthodontic tooth movement
- TGF-β