Effect of Encapsulation Beta Tri Calcium Phosphate (β -TCP) from the Synthesis of Anadara Granosa Shell as Pulp Capping Material against Inflammatory Cytokines IL-10 and TGF-β

Aprilia, Sri Kunarti, Theresia Indah Budhy, Rima Parwati Sari

Research output: Contribution to journalArticlepeer-review

Abstract

Pulp capping treatment is an endodontic treatment that aims to maintain the vitality of the pulp. Beta-tricalcium phosphate (β-TCP) has a chemical composition close to the structure of bones and teeth that can stimulate odontoblast to form dentin bridge. β-TCP can be obtained from anadara granosa hydrothermal process. This research intends to determine the effect of β-TCP encapsulation of anadara granosa clamshell against IL-10 and TGF β expression in dentin reparative formation. Thirty-six male Wistar rats were divided into six groups: control group (-), no-treatment group, CaOH group, and treatment with β-TCP. Application of pulp capping material on the M1 upper right tooth of Wistar rats that had been prepared for class I cavities. After seven days and 14 applications, the rats were euthanized, the prepared teeth were taken, and then IL-10 and TGFβ were examined. The data were then analyzed statistically (p<0.05). The analyzed data showed significant differences in each group.

Original languageEnglish
Pages (from-to)1522-1528
Number of pages7
JournalJournal of International Dental and Medical Research
Volume15
Issue number4
Publication statusPublished - 2022

Keywords

  • Calsium hydroxide
  • Il-10
  • Pulp capping
  • Tgfβ
  • Β-tcp

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