Introduction: IL-12 and IL-10 are cytokines with different mechanisms in the pathogenesis of COVID-19. Differences in IL-12 and IL-10 levels in patients receiving convalescent plasma and non-convalescent plasma recipients need to be known because the total levels of IL-12 and IL-10 also determine the clinical condition of the patient. Materials and Methods: This study used 40 randomly selected blood serum samples with details of 20 samples of COVID-19 patients without convalescent plasma therapy and 20 samples of COVID-19 patients. The COVID-19 patients at the Haji General Hospital in Surabaya provided the patient serum that was utilized. Results: Based on the findings, there were differences in IL-10 levels between the control group and convalescent plasma therapy recipients (P<0.05). On IL-12 levels had no difference between the control and treatment groups (P>0.05). Conclusion: According to statistical estimates, convalescent plasma treatment made a difference to IL-10 but not IL-12 levels in COVID-19 patients.

Original languageEnglish
Pages (from-to)19-22
Number of pages4
JournalMalaysian Journal of Medicine and Health Sciences
Publication statusPublished - Feb 2023


  • COVID-19
  • Convalescent plasma
  • IL-10
  • IL-12


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