Effect of cholecalciferol on GLUT4 expression in adipocyte of diabetic rats

Dewi Ratna Sari; Tri Hartini Yuliawati; Joni Susanto; Ari Gunawan; J. M. Harjanto

doi:10.15605/jafes.030.02.01

Effect of cholecalciferol on GLUT4 expression in adipocyte of diabetic rats

Dewi Ratna Sari, Rimbun, Tri Hartini Yuliawati, Joni Susanto, Ari Gunawan, J. M. Harjanto

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

This research was conducted to examine the effect of cholecalciferol on fasting blood glucose (FBG), adipocyte diameter and glucose transporter (GLUT) 4 expression in adipocytes of diabetic rats. Nineteen male Wistar strain diabetic rats were divided into 4 groups (K, X₁, X₂ and X₃). Cholecalciferol was administered in the amount of 6.25 μg/kg in X₁, 12.5 μg/kg in X₂ and 25 μg/kg in X₃ per orem, once daily for 14 days. Group K received the placebo. There were no significant differences in FBG (p=0.199) and adipocyte diameter (p=0.218) between groups but there were significant differences in the expression of GLUT4 between control and treatment groups. Thus, cholecalciferol can increase GLUT4 expression in adipocyte without altering FBG and adipocyte diameter of diabetic rats.

Original language	English
Pages (from-to)	190-193
Number of pages	4
Journal	Journal of the ASEAN Federation of Endocrine Societies
Volume	30
Issue number	2
DOIs	https://doi.org/10.15605/jafes.030.02.01
Publication status	Published - 1 Nov 2015

Keywords

Adipocyte
Cholecalciferol
Diabetes
GLUT4

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.15605/jafes.030.02.01

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title = "Effect of cholecalciferol on GLUT4 expression in adipocyte of diabetic rats",

abstract = "This research was conducted to examine the effect of cholecalciferol on fasting blood glucose (FBG), adipocyte diameter and glucose transporter (GLUT) 4 expression in adipocytes of diabetic rats. Nineteen male Wistar strain diabetic rats were divided into 4 groups (K, X1, X2 and X3). Cholecalciferol was administered in the amount of 6.25 μg/kg in X1, 12.5 μg/kg in X2 and 25 μg/kg in X3 per orem, once daily for 14 days. Group K received the placebo. There were no significant differences in FBG (p=0.199) and adipocyte diameter (p=0.218) between groups but there were significant differences in the expression of GLUT4 between control and treatment groups. Thus, cholecalciferol can increase GLUT4 expression in adipocyte without altering FBG and adipocyte diameter of diabetic rats.",

keywords = "Adipocyte, Cholecalciferol, Diabetes, GLUT4",

author = "Sari, {Dewi Ratna} and Rimbun and Yuliawati, {Tri Hartini} and Joni Susanto and Ari Gunawan and Harjanto, {J. M.}",

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AU - Sari, Dewi Ratna

AU - Rimbun,

AU - Yuliawati, Tri Hartini

AU - Susanto, Joni

AU - Gunawan, Ari

AU - Harjanto, J. M.

PY - 2015/11/1

Y1 - 2015/11/1

N2 - This research was conducted to examine the effect of cholecalciferol on fasting blood glucose (FBG), adipocyte diameter and glucose transporter (GLUT) 4 expression in adipocytes of diabetic rats. Nineteen male Wistar strain diabetic rats were divided into 4 groups (K, X1, X2 and X3). Cholecalciferol was administered in the amount of 6.25 μg/kg in X1, 12.5 μg/kg in X2 and 25 μg/kg in X3 per orem, once daily for 14 days. Group K received the placebo. There were no significant differences in FBG (p=0.199) and adipocyte diameter (p=0.218) between groups but there were significant differences in the expression of GLUT4 between control and treatment groups. Thus, cholecalciferol can increase GLUT4 expression in adipocyte without altering FBG and adipocyte diameter of diabetic rats.

AB - This research was conducted to examine the effect of cholecalciferol on fasting blood glucose (FBG), adipocyte diameter and glucose transporter (GLUT) 4 expression in adipocytes of diabetic rats. Nineteen male Wistar strain diabetic rats were divided into 4 groups (K, X1, X2 and X3). Cholecalciferol was administered in the amount of 6.25 μg/kg in X1, 12.5 μg/kg in X2 and 25 μg/kg in X3 per orem, once daily for 14 days. Group K received the placebo. There were no significant differences in FBG (p=0.199) and adipocyte diameter (p=0.218) between groups but there were significant differences in the expression of GLUT4 between control and treatment groups. Thus, cholecalciferol can increase GLUT4 expression in adipocyte without altering FBG and adipocyte diameter of diabetic rats.

KW - Adipocyte

KW - Cholecalciferol

KW - Diabetes

KW - GLUT4

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JO - Journal of the ASEAN Federation of Endocrine Societies

JF - Journal of the ASEAN Federation of Endocrine Societies

IS - 2

ER -

Effect of cholecalciferol on GLUT4 expression in adipocyte of diabetic rats

Abstract

Keywords

UN SDGs

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