TY - JOUR
T1 - Effect of CaCl2 crosslink solution concentration on the characteristics of gelatin alginate microspheres
AU - Safitri, Rizka
AU - Purwanti, Tutiek
AU - Soeratri, Widji
N1 - Publisher Copyright:
© 2020, Indian Journal of Forensic Medicine and Toxicology. All rights reserved.
PY - 2020/4/1
Y1 - 2020/4/1
N2 - Alginate as a constituent of microspheres matrix has a weakness, namely the lack of ability to slow the release of drugs from the system, causing the effects of drug therapy to the body to be less than optimal. To obtain preparations with slowed release, sodium alginate needs to be combined with other polymers such as gelatin. This study aims to determine the effect of the concentration of CaCl 2 connection solution on the characteristics of alginate-gelatin microspheres. In this study, alginate-gelatin microspheres were prepared using ionotropic gelation aerosolization techniques. Three formulas were made, each of which was replicated three times. F1 with CaCl concentration2 0.5 M, F2 with CaCl concentration2 1.0 M, F3 with a concentration of 1.5 M. The three formulas were made in the ratio of alginate-gelatin (1.5: 1)% and a crosslinking time of 1.5 hours. Evaluation of the characteristics of microspheres includes yield percentage, organoleptic, moisture content, morphology of microspheres, size and size distribution of microspheres, and swelling index. The data of this study were analyzed using one way ANNOVA. The results reveals a loss of specific uptake of the COO-manuronate alginate group and the occurrence of wave number shifts as well as an increase in the absorption intensity of the C = O group. Organoleptic examination results of alginate-gelatinin microspheres showed that microspheres of the three formulas had the same organoleptic, and formed spherical microspheres. On the inspection of swelling index, it was found that F1 and F2 reached the peak of swelling at 2 o’clock, while F3 reaches the peak of swelling at 3 o’clock. The greater the level of CaCl2, then the average diameter of microspheres will also increase, while the swelling index will decrease with increasing levels of CaCl2. In the results of moisture content examination, there is no difference in different CaCl 2.
AB - Alginate as a constituent of microspheres matrix has a weakness, namely the lack of ability to slow the release of drugs from the system, causing the effects of drug therapy to the body to be less than optimal. To obtain preparations with slowed release, sodium alginate needs to be combined with other polymers such as gelatin. This study aims to determine the effect of the concentration of CaCl 2 connection solution on the characteristics of alginate-gelatin microspheres. In this study, alginate-gelatin microspheres were prepared using ionotropic gelation aerosolization techniques. Three formulas were made, each of which was replicated three times. F1 with CaCl concentration2 0.5 M, F2 with CaCl concentration2 1.0 M, F3 with a concentration of 1.5 M. The three formulas were made in the ratio of alginate-gelatin (1.5: 1)% and a crosslinking time of 1.5 hours. Evaluation of the characteristics of microspheres includes yield percentage, organoleptic, moisture content, morphology of microspheres, size and size distribution of microspheres, and swelling index. The data of this study were analyzed using one way ANNOVA. The results reveals a loss of specific uptake of the COO-manuronate alginate group and the occurrence of wave number shifts as well as an increase in the absorption intensity of the C = O group. Organoleptic examination results of alginate-gelatinin microspheres showed that microspheres of the three formulas had the same organoleptic, and formed spherical microspheres. On the inspection of swelling index, it was found that F1 and F2 reached the peak of swelling at 2 o’clock, while F3 reaches the peak of swelling at 3 o’clock. The greater the level of CaCl2, then the average diameter of microspheres will also increase, while the swelling index will decrease with increasing levels of CaCl2. In the results of moisture content examination, there is no difference in different CaCl 2.
KW - Aerosolization
KW - Alginate
KW - CaCl
KW - Gelatin
KW - Ionotrophic gelation
KW - Microspheres
UR - http://www.scopus.com/inward/record.url?scp=85087403209&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:85087403209
SN - 0973-9122
VL - 14
SP - 1909
EP - 1915
JO - Indian Journal of Forensic Medicine and Toxicology
JF - Indian Journal of Forensic Medicine and Toxicology
IS - 2
ER -