The promoting effect of bile salts-lecithin mixed micelle formulations on the skin permeation of diclofenac was investigated in rats in vitro. The flux of diclofenac significantly increased by the administration of bile salts-lecithin mixed micelles compared with that of simple micelles of bile salts. The mixed micelles dissolved diclofenac in a greater amount compared with that of simple micelles. Therefore, we suggest that the diclofenac solubility in the mixed micelles was a primary factor of the enhancement of diclofenac flux. The flux would increase by an additive amount of bile salts in the mixed micelle formulations. The greater flux was observed in sodium deoxycholate mixed micelles compared with that of sodium cholate. The flux significantly increased when either d-limonene or l-menthol was incorporated in the mixed micelles. The ability to solubilize d-limonene and l-menthol without organic solvent may be considered as an advantage of the mixed micelle formulations.
|Number of pages||5|
|Journal||S.T.P. Pharma Sciences|
|Publication status||Published - Jul 2003|
- Bile salts-lecithin mixed micelle formulations
- Sodium cholate
- Sodium deoxycholate
- Transdermal drug delivery