Effect of aloe vera extracts towards the fibroblast number and collagen thickness on clean skin wound healing on rattus novergicus

Currently, there are many agents that can improve the healing process, one of which is Aloe vera extract. This study aimed to prove the effect of Aloe vera and tulle extracts on the healing of clean wounds on rat skin. This was a laboratory experimental study in white rats using the treatment of Aloe vera, tulle, and normal saline extract on clean skin wounds. Data on body weight and age of the sample used in this study were all homogeneous (p >0.05). The mean number of fibroblasts in control group was 72.18±28.35, Aloe vera group was 129.3±33.27, and tulle group was 84±18.85. The Aloe vera administration group had more fibroblasts and was statistically significant compared to the other groups (p = 0.011), although there was no significant difference in the collagen thickness score among three groups (p = 0.801). Aloe vera extract can increase the number of fibroblasts in the clean wound healing process.