Effect of Allopurinol administration on the uric acid level and kidney function in paediatrics with tumour lysis syndrome (TLS) and high-risk TLS

Yulistiani, Indira Dhany Kharismawati, I. Dewa Gede Ugrasena, Mariyatul Qibtiyah

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Tumor lysis syndrome (TLS) is a life-threatening oncologic emergency because of the release of tumour cell components such as uric acid, which can lead to hyperuricemia and acute kidney injury (AKI). Objective: To analyse serum uric acid, creatinine, and BUN levels pre-and post-allopurinol administration. Method: This study was a prospective observational study conducted from March to July 2020. Inclusion criteria were haematological malignancies in paediatric patients with TLS and high-risk TLS who received allopurinol 10 mg/kg/day in 2-3 divided doses. Collected data were the serum uric acid, creatinine, and BUN levels pre-and post-allopurinol administration. Result: There were 14 sample in total during the study. There was a significant difference in uric acid level on day six after allopurinol administration compared to baseline in patients with high-risk TLS (p < 0.05). Conclusion: Allopurinol was inadequate in reducing uric acid levels in TLS patients but adequate in reducing uric acid levels in patients with high-risk TLS.

Original languageEnglish
Pages (from-to)87-91
Number of pages5
JournalPharmacy Education
Volume23
Issue number4
DOIs
Publication statusPublished - 21 Jan 2023

Keywords

  • Allopurinol
  • Creatinine serum
  • Paediatric
  • Tumour lysis syndrome
  • Uric acid

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