Efektivitas Krim Ekstrak Buah Naga Merah (Hylocereus polyrhizus) dalam Meningkatkan Jumlah Sel Fibroblas Luka Bakar Derajat II pada Tikus Putih (Rattus norvegicus)

This study aimed to find out the effectiveness of red dragon fruit (Hylocereus polyrhizus) extract cream in increasing amount of fibroblast cells in second degree burns in white rats (Rattus norvegicus). Twenty male rats (Rattus novegicus) divided into five treatment groups with four repetitions respectively. All of them were induced with second degree burns. Negative control (K-) group treated with oil in water cream base. Positive control (K+) treated with Bi oplacenton®. P1, P2 and P3 group treated with 7.5%, 15% and 30% red dragon fruit (Hylocereus polyrhizus) extract cream. Therapy was given twice a day for 10 days. Kolmogorov-Smirnov test showed that the data distribution is normal (p>0.05), continued with Oneway ANOVA test that showed significant different from each groups (p<0.05) and continued with Post-Hoc LSD test. Average amount of fibroblast cells from each groups showed that K-group and K+ group is significanly different from P1, P2 and P3 group. P2 group showed the highest fibroblasts amount. The conclusion of this study is red dragon fruit extract (Hylocereus polyrhizus) cream can increase the amount of fibroblast cells in second degree burns in white rat’s (Rattus norvegicus) skin.