Abstract
The aim of this research was to determine the effectiveness of bitter leaf (Vernonia amygdalina) extract topically can accelerate the density of collagen on incision wound healing in rats (Rattus norvegicus). Twenty male rats were randomly devided into five groups, there were negative control (K-) treated with ointment base, positive control (K+) treated with povidone iodine 10% ointment, treated groups (P1, P2, P3) treated with bitter leaf extract ointment 16,8%; 28%; and 39,2% . Treatment had been given directly on the subcutan incision area topically twice a day for fourteen days. On the day fourteen of this research samples were dissected and taken to the skin organ preparation for histophatology test. The data of histopatological appereance were processed with Kruskal-Wallis using SPSS 20. The result showed is p = 0,077 that is no signicantly different (p>0,05) between treatment. Based on the result the average P1 has highest density of collagen than the others treatment. This research concluded that bitter leaf (Vernonia amygdalina) can not accelerate density of collagen on incision wound healing in rats.
Translated title of the contribution | (EFFECTIVITY OF BITTER LEAF EXTRACT (Vernonia amygdalina) TOPICALLY ON COLLAGEN DENSITY ON INCISION WOUND HEALING IN RATS (Rattus norvegicus)) |
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Original language | Indonesian |
Pages (from-to) | 36-41 |
Number of pages | 6 |
Journal | Jurnal Medik Veteriner |
Volume | 2 |
Issue number | 1 |
DOIs | |
Publication status | Published - Apr 2019 |
Keywords
- Vernonia amygdalina
- collagen density
- wound healing