Efek Antidiabetik Ekstrak Daun Gendola (Basella rubra L.) Terhadap Kadar Gula Darah Tikus Putih

This study aimed to measure the effect of ethanol extract of gendola leaves (Basella rubra L.) on decreasing blood glucose levels in albino rats (Rattus norvegicus) induced by Alloxan. This study was an experimental study using 35 albino rats. The rats were divided into five groups, i.e., treatment group P1; P2; P3; negative control (K-); and positive control (K+). Each group was induced with Alloxan to increase blood glucose levels. P1; P2; P3 groups were given 200; 300; 400 mg/kgBW/day dosage of gendola leaf extract dose, while the K+ group was given glimepirid 0.1 kg/kgBW/day. Group P1 had an insignificant decrease in blood glucose levels by 30.14 mg/dL (p-value=0.128); P2 group experienced an insignificant decrease in blood glucose levels by 25.80 mg/dL (p-value=0.159); the P3 group had a significant decrease in blood glucose levels by 42.80 mg/dL (p-value=0.043). The negative control group had an increase in blood glucose level by 116.00 mg/dL (p-value=0.084). The positive control group had a significant decrease in blood glucose levels by 21.60 mg/dL (p-value=0.011). Gendola leaf extract with the dosage of 400 mg/kgBW/day can reduce blood glucose levels in albino rats with insignificant difference when compared with antidiabetic drug such as glimepirid 0.1 mg/kgBW/day.