(E)-3-[3-(4-morpholinophenyl)acryloyl]-2H-chromen-2-one

Hery Suwito; Helda Dwi Hardiyanti; Kautsar Ul Haq; Alfinda Novi Kristanti; Miratul Khasanah

doi:10.3390/M1027

(E)-3-[3-(4-morpholinophenyl)acryloyl]-2H-chromen-2-one

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

A new compound (E)-3-[3-(4-morpholinophenyl)acryloyl]-2H-chromen-2-one, a coumarin based chalcone derivative, has been successfully synthesized employing a molecular hybridization method through the reaction between 3-acetylcoumarin and 4-morpholinobenzaldehyde using a Claisen–Schmidt reaction using pTSA as a catalyst. The structure of the title compound was established using spectroscopic data FTIR, HRESI-MS,¹H- and ¹³C-NMR. The anticancer activity against breast cancer cells line T47D and cervix cancer cells line HeLa was determined using an MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay.

Original language	English
Article number	M1027
Journal	MolBank
Volume	2018
Issue number	4
DOIs	https://doi.org/10.3390/M1027
Publication status	Published - Dec 2018

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Anticancer
Coumarin-chalcone
Molecular hybridization

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10.3390/M1027

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title = "(E)-3-[3-(4-morpholinophenyl)acryloyl]-2H-chromen-2-one",

abstract = "A new compound (E)-3-[3-(4-morpholinophenyl)acryloyl]-2H-chromen-2-one, a coumarin based chalcone derivative, has been successfully synthesized employing a molecular hybridization method through the reaction between 3-acetylcoumarin and 4-morpholinobenzaldehyde using a Claisen–Schmidt reaction using pTSA as a catalyst. The structure of the title compound was established using spectroscopic data FTIR, HRESI-MS,1H- and 13C-NMR. The anticancer activity against breast cancer cells line T47D and cervix cancer cells line HeLa was determined using an MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay.",

keywords = "Anticancer, Coumarin-chalcone, Molecular hybridization",

author = "Hery Suwito and Hardiyanti, \{Helda Dwi\} and \{Ul Haq\}, Kautsar and Kristanti, \{Alfinda Novi\} and Miratul Khasanah",

note = "Publisher Copyright: {\textcopyright} 2018 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2018",

month = dec,

doi = "10.3390/M1027",

language = "English",

volume = "2018",

journal = "MolBank",

issn = "1422-8599",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

number = "4",

}

TY - JOUR

T1 - (E)-3-[3-(4-morpholinophenyl)acryloyl]-2H-chromen-2-one

AU - Suwito, Hery

AU - Hardiyanti, Helda Dwi

AU - Ul Haq, Kautsar

AU - Kristanti, Alfinda Novi

AU - Khasanah, Miratul

PY - 2018/12

Y1 - 2018/12

N2 - A new compound (E)-3-[3-(4-morpholinophenyl)acryloyl]-2H-chromen-2-one, a coumarin based chalcone derivative, has been successfully synthesized employing a molecular hybridization method through the reaction between 3-acetylcoumarin and 4-morpholinobenzaldehyde using a Claisen–Schmidt reaction using pTSA as a catalyst. The structure of the title compound was established using spectroscopic data FTIR, HRESI-MS,1H- and 13C-NMR. The anticancer activity against breast cancer cells line T47D and cervix cancer cells line HeLa was determined using an MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay.

AB - A new compound (E)-3-[3-(4-morpholinophenyl)acryloyl]-2H-chromen-2-one, a coumarin based chalcone derivative, has been successfully synthesized employing a molecular hybridization method through the reaction between 3-acetylcoumarin and 4-morpholinobenzaldehyde using a Claisen–Schmidt reaction using pTSA as a catalyst. The structure of the title compound was established using spectroscopic data FTIR, HRESI-MS,1H- and 13C-NMR. The anticancer activity against breast cancer cells line T47D and cervix cancer cells line HeLa was determined using an MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay.

KW - Anticancer

KW - Coumarin-chalcone

KW - Molecular hybridization

UR - https://www.scopus.com/pages/publications/85057154606

U2 - 10.3390/M1027

DO - 10.3390/M1027

M3 - Article

AN - SCOPUS:85057154606

SN - 1422-8599

VL - 2018

JO - MolBank

JF - MolBank

IS - 4

M1 - M1027

ER -

(E)-3-[3-(4-morpholinophenyl)acryloyl]-2H-chromen-2-one

Abstract

UN SDGs

Keywords

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