(E)-3-[3-(4-morpholinophenyl)acryloyl]-2H-chromen-2-one

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8 Citations (Scopus)

Abstract

A new compound (E)-3-[3-(4-morpholinophenyl)acryloyl]-2H-chromen-2-one, a coumarin based chalcone derivative, has been successfully synthesized employing a molecular hybridization method through the reaction between 3-acetylcoumarin and 4-morpholinobenzaldehyde using a Claisen–Schmidt reaction using pTSA as a catalyst. The structure of the title compound was established using spectroscopic data FTIR, HRESI-MS,1H- and 13C-NMR. The anticancer activity against breast cancer cells line T47D and cervix cancer cells line HeLa was determined using an MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay.

Original languageEnglish
Article numberM1027
JournalMolBank
Volume2018
Issue number4
DOIs
Publication statusPublished - Dec 2018

Keywords

  • Anticancer
  • Coumarin-chalcone
  • Molecular hybridization

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