Dukunolide G: A New Limonoid from the Root of Lansium domesticum Corr. (Meliaceae)

Rudiyansyah, Andi Hairil Alimuddin, Yuliati Indrayani, Salma Zulqaida, Yoshiaki Takaya

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1 Citation (Scopus)


The Lansium genus belongs to the Meliaceae which is well known for limonoids. Limonoid is triterpenoid derivatives that have various structures due to rearrangements and degree oxidation. Lansium domesticum is a trunked tree growing more than 20 m in hight and it has antifeedant and antimalarial activities. Phytochemical investigations have been conducted toward fruits, leaves, and bark of this plant, except for the root. Methanol root extract of L. domesticum was fractionated by chromatography techniques including C18-HPLC to isolate pure compounds. Exploration of secondary metabolites from the root of L. domesticum has resulted a new limonoid attached with an isopropyl moeity, dukunolide G (1) together with four known constituents, dukunolides A-C (2–4) and langsatide B (5). The chemical structures were characterized by 1D and 2D NMR (COSY, HSQC, HMBC), [α]D values including DART-HRMS, and comparing with literature. Antimalarial activity of isolated compounds against Plasmodium falciparum strain 3D7 were evaluated and the results revealed that compounds 1 and 4 has strong and medium activities with IC50 values 0.48 and 2.74 mg/mL, respectively. Graphical Abstract: [Figure not available: see fulltext.]

Original languageEnglish
Pages (from-to)2199-2203
Number of pages5
JournalChemistry Africa
Issue number4
Publication statusPublished - Aug 2023


  • Antimalaria
  • Lansium domesticum
  • Limonoid
  • Meliaceae


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