Drivers of and Barriers to COVID-19 Vaccine Booster Dose Acceptance in Indonesia

Harapan Harapan; Raisha Fathima; Hendrix Indra Kusuma; Samsul Anwar; Widhy Yudistira Nalapraya; Adityo Wibowo; Ketut Dewi Kumara Wati; Ayunda Medina; Anna Hanifa Defrita; Yesi Astri; Arie Prasetyowati; Nurfarahin Nurfarahin; Afriyani Khusna; Setya Oktariana; Sarifuddin Anwar; Milza Oka Yussar; Siti Khotimah; Bahagia Willibrordus Maria Nainggolan; Putri Rizki Amalia Badri; Raden Argarini; Wira Winardi; Rosaria Indah; Malik Sallam; Yogambigai Rajamoorthy; Abram L. Wagner; Mudatsir Mudatsir

doi:10.3390/vaccines10121981

Drivers of and Barriers to COVID-19 Vaccine Booster Dose Acceptance in Indonesia

Harapan Harapan, Raisha Fathima, Hendrix Indra Kusuma, Samsul Anwar, Widhy Yudistira Nalapraya, Adityo Wibowo, Ketut Dewi Kumara Wati, Ayunda Medina, Anna Hanifa Defrita, Yesi Astri, Arie Prasetyowati, Nurfarahin Nurfarahin, Afriyani Khusna, Setya Oktariana, Sarifuddin Anwar, Milza Oka Yussar, Siti Khotimah, Bahagia Willibrordus Maria Nainggolan, Putri Rizki Amalia Badri, Raden ArgariniWira Winardi, Rosaria Indah, Malik Sallam, Yogambigai Rajamoorthy, Abram L. Wagner, Mudatsir Mudatsir

Research output: Contribution to journal › Article › peer-review

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Abstract

Obtaining a booster dose of coronavirus disease 2019 (COVID-19) vaccine is required to maintain the protective level of neutralizing antibodies and therefore herd immunity in the community, and the success of booster dose programs depends on public acceptance. The aim of this study was to determine the acceptance of a booster dose of COVID-19 vaccine and its drivers and barriers in Indonesia. A cross-sectional survey was conducted in the provinces of Indonesia between 1 and 15 August 2022. Individuals who completed the primary series of the COVID-19 vaccine were asked about their acceptance of a booster dose. Those who refused the booster dose were questioned about their reasons. A logistic regression was used to determine the determinants associated with rejection of a booster dose of COVID-19 vaccine. A total of 2935 respondents were included in the final analysis. With no information on the efficacy and safety of the COVID-19 vaccine, 95% of respondents agreed to receive a booster dose if it were provided for free by the government. This acceptance was reduced to only 50.3% if the vaccine had a 75% efficacy with a 20% chance of side effects. The adjusted logistic regression analysis indicated that there were eight factors associated with the rejection of the booster dose: age, marital status, religion, occupation, type of the first two vaccines received, knowledge regarding the importance of the booster dose, belief that natural immunity is sufficient to prevent COVID-19 and disbelief in the effectiveness of the booster dose. In conclusion, the hesitancy toward booster doses in Indonesia is influenced by some intrinsic factors such as lack of knowledge on the benefits of the booster dose, worries regarding the unexpected side effects and concerns about the halal status of the provided vaccines and extrinsic determinants such as the effectiveness and safety of the vaccine. These findings suggest the need for more campaigns and promotions regarding the booster dose benefits to increase its acceptance.

Original language	English
Article number	1981
Journal	Vaccines
Volume	10
Issue number	12
DOIs	https://doi.org/10.3390/vaccines10121981
Publication status	Published - Dec 2022

Keywords

COVID-19
booster dose
vaccine acceptance
vaccine hesitancy
vaccine rejection
vaccine reluctance
vaccine resistance

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/vaccines10121981

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Harapan, H., Fathima, R., Kusuma, H. I., Anwar, S., Nalapraya, W. Y., Wibowo, A., Wati, K. D. K., Medina, A., Defrita, A. H., Astri, Y., Prasetyowati, A., Nurfarahin, N., Khusna, A., Oktariana, S., Anwar, S., Yussar, M. O., Khotimah, S., Nainggolan, B. W. M., Badri, P. R. A., ... Mudatsir, M. (2022). Drivers of and Barriers to COVID-19 Vaccine Booster Dose Acceptance in Indonesia. Vaccines, 10(12), Article 1981. https://doi.org/10.3390/vaccines10121981

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title = "Drivers of and Barriers to COVID-19 Vaccine Booster Dose Acceptance in Indonesia",

abstract = "Obtaining a booster dose of coronavirus disease 2019 (COVID-19) vaccine is required to maintain the protective level of neutralizing antibodies and therefore herd immunity in the community, and the success of booster dose programs depends on public acceptance. The aim of this study was to determine the acceptance of a booster dose of COVID-19 vaccine and its drivers and barriers in Indonesia. A cross-sectional survey was conducted in the provinces of Indonesia between 1 and 15 August 2022. Individuals who completed the primary series of the COVID-19 vaccine were asked about their acceptance of a booster dose. Those who refused the booster dose were questioned about their reasons. A logistic regression was used to determine the determinants associated with rejection of a booster dose of COVID-19 vaccine. A total of 2935 respondents were included in the final analysis. With no information on the efficacy and safety of the COVID-19 vaccine, 95% of respondents agreed to receive a booster dose if it were provided for free by the government. This acceptance was reduced to only 50.3% if the vaccine had a 75% efficacy with a 20% chance of side effects. The adjusted logistic regression analysis indicated that there were eight factors associated with the rejection of the booster dose: age, marital status, religion, occupation, type of the first two vaccines received, knowledge regarding the importance of the booster dose, belief that natural immunity is sufficient to prevent COVID-19 and disbelief in the effectiveness of the booster dose. In conclusion, the hesitancy toward booster doses in Indonesia is influenced by some intrinsic factors such as lack of knowledge on the benefits of the booster dose, worries regarding the unexpected side effects and concerns about the halal status of the provided vaccines and extrinsic determinants such as the effectiveness and safety of the vaccine. These findings suggest the need for more campaigns and promotions regarding the booster dose benefits to increase its acceptance.",

keywords = "COVID-19, booster dose, vaccine acceptance, vaccine hesitancy, vaccine rejection, vaccine reluctance, vaccine resistance",

author = "Harapan Harapan and Raisha Fathima and Kusuma, {Hendrix Indra} and Samsul Anwar and Nalapraya, {Widhy Yudistira} and Adityo Wibowo and Wati, {Ketut Dewi Kumara} and Ayunda Medina and Defrita, {Anna Hanifa} and Yesi Astri and Arie Prasetyowati and Nurfarahin Nurfarahin and Afriyani Khusna and Setya Oktariana and Sarifuddin Anwar and Yussar, {Milza Oka} and Siti Khotimah and Nainggolan, {Bahagia Willibrordus Maria} and Badri, {Putri Rizki Amalia} and Raden Argarini and Wira Winardi and Rosaria Indah and Malik Sallam and Yogambigai Rajamoorthy and Wagner, {Abram L.} and Mudatsir Mudatsir",

note = "Publisher Copyright: {\textcopyright} 2022 by the authors.",

year = "2022",

month = dec,

doi = "10.3390/vaccines10121981",

language = "English",

volume = "10",

journal = "Vaccines",

issn = "2076-393X",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

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Harapan, H, Fathima, R, Kusuma, HI, Anwar, S, Nalapraya, WY, Wibowo, A, Wati, KDK, Medina, A, Defrita, AH, Astri, Y, Prasetyowati, A, Nurfarahin, N, Khusna, A, Oktariana, S, Anwar, S, Yussar, MO, Khotimah, S, Nainggolan, BWM, Badri, PRA, Argarini, R, Winardi, W, Indah, R, Sallam, M, Rajamoorthy, Y, Wagner, AL & Mudatsir, M 2022, 'Drivers of and Barriers to COVID-19 Vaccine Booster Dose Acceptance in Indonesia', Vaccines, vol. 10, no. 12, 1981. https://doi.org/10.3390/vaccines10121981

TY - JOUR

T1 - Drivers of and Barriers to COVID-19 Vaccine Booster Dose Acceptance in Indonesia

AU - Harapan, Harapan

AU - Fathima, Raisha

AU - Kusuma, Hendrix Indra

AU - Anwar, Samsul

AU - Nalapraya, Widhy Yudistira

AU - Wibowo, Adityo

AU - Wati, Ketut Dewi Kumara

AU - Medina, Ayunda

AU - Defrita, Anna Hanifa

AU - Astri, Yesi

AU - Prasetyowati, Arie

AU - Nurfarahin, Nurfarahin

AU - Khusna, Afriyani

AU - Oktariana, Setya

AU - Anwar, Sarifuddin

AU - Yussar, Milza Oka

AU - Khotimah, Siti

AU - Nainggolan, Bahagia Willibrordus Maria

AU - Badri, Putri Rizki Amalia

AU - Argarini, Raden

AU - Winardi, Wira

AU - Indah, Rosaria

AU - Sallam, Malik

AU - Rajamoorthy, Yogambigai

AU - Wagner, Abram L.

AU - Mudatsir, Mudatsir

PY - 2022/12

Y1 - 2022/12

N2 - Obtaining a booster dose of coronavirus disease 2019 (COVID-19) vaccine is required to maintain the protective level of neutralizing antibodies and therefore herd immunity in the community, and the success of booster dose programs depends on public acceptance. The aim of this study was to determine the acceptance of a booster dose of COVID-19 vaccine and its drivers and barriers in Indonesia. A cross-sectional survey was conducted in the provinces of Indonesia between 1 and 15 August 2022. Individuals who completed the primary series of the COVID-19 vaccine were asked about their acceptance of a booster dose. Those who refused the booster dose were questioned about their reasons. A logistic regression was used to determine the determinants associated with rejection of a booster dose of COVID-19 vaccine. A total of 2935 respondents were included in the final analysis. With no information on the efficacy and safety of the COVID-19 vaccine, 95% of respondents agreed to receive a booster dose if it were provided for free by the government. This acceptance was reduced to only 50.3% if the vaccine had a 75% efficacy with a 20% chance of side effects. The adjusted logistic regression analysis indicated that there were eight factors associated with the rejection of the booster dose: age, marital status, religion, occupation, type of the first two vaccines received, knowledge regarding the importance of the booster dose, belief that natural immunity is sufficient to prevent COVID-19 and disbelief in the effectiveness of the booster dose. In conclusion, the hesitancy toward booster doses in Indonesia is influenced by some intrinsic factors such as lack of knowledge on the benefits of the booster dose, worries regarding the unexpected side effects and concerns about the halal status of the provided vaccines and extrinsic determinants such as the effectiveness and safety of the vaccine. These findings suggest the need for more campaigns and promotions regarding the booster dose benefits to increase its acceptance.

AB - Obtaining a booster dose of coronavirus disease 2019 (COVID-19) vaccine is required to maintain the protective level of neutralizing antibodies and therefore herd immunity in the community, and the success of booster dose programs depends on public acceptance. The aim of this study was to determine the acceptance of a booster dose of COVID-19 vaccine and its drivers and barriers in Indonesia. A cross-sectional survey was conducted in the provinces of Indonesia between 1 and 15 August 2022. Individuals who completed the primary series of the COVID-19 vaccine were asked about their acceptance of a booster dose. Those who refused the booster dose were questioned about their reasons. A logistic regression was used to determine the determinants associated with rejection of a booster dose of COVID-19 vaccine. A total of 2935 respondents were included in the final analysis. With no information on the efficacy and safety of the COVID-19 vaccine, 95% of respondents agreed to receive a booster dose if it were provided for free by the government. This acceptance was reduced to only 50.3% if the vaccine had a 75% efficacy with a 20% chance of side effects. The adjusted logistic regression analysis indicated that there were eight factors associated with the rejection of the booster dose: age, marital status, religion, occupation, type of the first two vaccines received, knowledge regarding the importance of the booster dose, belief that natural immunity is sufficient to prevent COVID-19 and disbelief in the effectiveness of the booster dose. In conclusion, the hesitancy toward booster doses in Indonesia is influenced by some intrinsic factors such as lack of knowledge on the benefits of the booster dose, worries regarding the unexpected side effects and concerns about the halal status of the provided vaccines and extrinsic determinants such as the effectiveness and safety of the vaccine. These findings suggest the need for more campaigns and promotions regarding the booster dose benefits to increase its acceptance.

KW - COVID-19

KW - booster dose

KW - vaccine acceptance

KW - vaccine hesitancy

KW - vaccine rejection

KW - vaccine reluctance

KW - vaccine resistance

UR - http://www.scopus.com/inward/record.url?scp=85144567425&partnerID=8YFLogxK

U2 - 10.3390/vaccines10121981

DO - 10.3390/vaccines10121981

M3 - Article

AN - SCOPUS:85144567425

SN - 2076-393X

VL - 10

JO - Vaccines

JF - Vaccines

IS - 12

M1 - 1981

ER -

Drivers of and Barriers to COVID-19 Vaccine Booster Dose Acceptance in Indonesia

Abstract

Keywords

UN SDGs

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