TY - JOUR
T1 - Do Vitamin D receptor gene polymorphisms affect bone mass density in men?
T2 - A meta-analysis of observational studies
AU - Pakpahan, Cennikon
AU - Wungu, Citrawati Dyah Kencono
AU - Agustinus, Agustinus
AU - Darmadi, Darmadi
N1 - Publisher Copyright:
© 2022 Elsevier B.V.
PY - 2022/3
Y1 - 2022/3
N2 - The signs of aging in humans can often be detected through a decrease in bone mass density (BMD). The decrease in BMD as a risk of osteoporosis is often only seen in women, but not in men, even though men also have a risk of osteoporosis which can affect their well-being. We conducted study searches through databases such as PubMed, EBSCO, ProQuest, Willey Online, Science Direct, and SAGE. We performed analysis on four types of Vitamin D receptor polymorphisms: BsmI, ApaI, FokI, and TaqI from 14 potential studies involving men. We found that several genetic analysis models of BsmI and FokI significantly affected BMD in men: BB vs bb in whole body BMD (SMD = 0.43, 95% CI = [0.12–0.75], p = 0.0008, BB vs Bb in whole body BMD (SMD = −1.38, 95% CI = [−1.87 to 0.88], p < 0.00001), and FF+Ff vs ff spine BMD (SMD = 0.59, 95% CI = 0.13–1.05], p = 0.001), even after adjusting for comorbidities as confounding variables. The present meta-analysis showed that BsmI and FokI polymorphisms of the VDR gene were correlated with decreased BMD in men which may contribute to the aging process and well-being.
AB - The signs of aging in humans can often be detected through a decrease in bone mass density (BMD). The decrease in BMD as a risk of osteoporosis is often only seen in women, but not in men, even though men also have a risk of osteoporosis which can affect their well-being. We conducted study searches through databases such as PubMed, EBSCO, ProQuest, Willey Online, Science Direct, and SAGE. We performed analysis on four types of Vitamin D receptor polymorphisms: BsmI, ApaI, FokI, and TaqI from 14 potential studies involving men. We found that several genetic analysis models of BsmI and FokI significantly affected BMD in men: BB vs bb in whole body BMD (SMD = 0.43, 95% CI = [0.12–0.75], p = 0.0008, BB vs Bb in whole body BMD (SMD = −1.38, 95% CI = [−1.87 to 0.88], p < 0.00001), and FF+Ff vs ff spine BMD (SMD = 0.59, 95% CI = 0.13–1.05], p = 0.001), even after adjusting for comorbidities as confounding variables. The present meta-analysis showed that BsmI and FokI polymorphisms of the VDR gene were correlated with decreased BMD in men which may contribute to the aging process and well-being.
KW - Aging
KW - Bone mass density
KW - Polymorphisms
KW - Vitamin D gene receptor
KW - Well-being
UR - http://www.scopus.com/inward/record.url?scp=85123119940&partnerID=8YFLogxK
U2 - 10.1016/j.arr.2022.101571
DO - 10.1016/j.arr.2022.101571
M3 - Review article
AN - SCOPUS:85123119940
SN - 1568-1637
VL - 75
JO - Ageing Research Reviews
JF - Ageing Research Reviews
M1 - 101571
ER -