Disturbance of B-vitamin status in people with type 2 diabetes in Indonesia-Link to renal status, glycemic control and vascular inflammation

Antonysunil Adaikalakoteswari, Naila Rabbani, Sarwono Waspadji, Askandar Tjokroprawiro, Sri H.K.S. Kariadi, John M.F. Adam, Paul J. Thornalley

Research output: Contribution to journalArticlepeer-review

26 Citations (Scopus)

Abstract

Background: Diabetes is associated with mishandling of thiamine in the kidney and development of diabetic nephropathy. The aim of this study is to assess the disturbance of thiamine and other B-vitamin status of patients with type 2 diabetes in Indonesia. Methods: One hundred and fifteen patients with type 2 diabetes with and without microalbuminuria or albuminuria and 39 healthy people were recruited. After a 2-month washout period for B-vitamin supplementation, markers of vitamins B 1, B 6, B 9 and B 12, were determined. Results: Fractional excretion of thiamine (22.8 versus 33.5%; P<0.05) and urinary excretion of the vitamin B 6 degradation product 4-pyridoxic acid (0.081 versus 0.133μmol/g creatinine, P<0.001) was increased in patients with type 2 diabetes with respect to healthy controls. There was also increased total plasma cobalamin (398 versus 547pmol/l, P<0.001) and holotranscobalamin (74 versus 97pmol/l, P<0.001) in patients with type 2 diabetes. In multiple regression analysis these were linked to HbA1c, duration of diabetes and systolic blood pressure, and fasting plasma glucose, folate and C-reactive protein, respectively. Conclusions: There was renal mishandling of thiamine, increased degradation of vitamin B 6 and cytosolic metabolic resistance to vitamin B 12 in patients with type 2 diabetes in Indonesia.

Original languageEnglish
Pages (from-to)415-424
Number of pages10
JournalDiabetes Research and Clinical Practice
Volume95
Issue number3
DOIs
Publication statusPublished - Mar 2012

Keywords

  • Cobalamin
  • Diabetic nephropathy
  • Folate
  • Pyridoxine
  • Thiamine
  • Type 2 diabetes
  • Vascular inflammation

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