Distribution of G6PD deficiency genotypes among Southeast Asian populations

Indah S. Tantular, Fumihiko Kawamoto

Research output: Contribution to journalReview articlepeer-review

8 Citations (Scopus)

Abstract

Glucose-6-phosphate dehydrogenase (G6PD) deficiency is a group of X-linked, hereditary genetic disorders caused by mutations in the G6PD gene and results in functional variants of about 400 biochemical and clinical phenotypes. Among them, more than 215 genotypes have been identified so far. In this review, specific features of the genotype distribution in different communities and countries are discussed based on multiple reports and our molecular epidemiological studies of Southeast Asian countries. Particularly, in Indonesia, the frequency distribution of G6PD deficiency variants was distinct between western and eastern Indonesian populations, suggesting two different gene flows during Indonesian expansions.

Original languageEnglish
Article number97
JournalTropical Medicine and Health
Volume49
Issue number1
DOIs
Publication statusPublished - Dec 2021

Keywords

  • Distribution
  • G6PD deficiency
  • Genotype
  • Glucose-6-phosphate dehydrogenase
  • Southeast Asian population

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