TY - JOUR
T1 - Disintegration, in vitro Dissolution, and Drug Release Kinetics Profiles of k-Carrageenan-based Nutraceutical Hard-shell Capsules Containing Salicylamide
AU - Pudjiastuti, Pratiwi
AU - Wafiroh, Siti
AU - Hendradi, Esti
AU - Darmokoesoemo, Handoko
AU - Harsini, Muji
AU - Fauzi, M. Al Rizqi Dharma
AU - Nahar, Lutfun
AU - Sarker, Satyajit D.
N1 - Funding Information:
The authors thank the Ministry of Research, Technology and Higher Education, Indonesia for the research support fund through the Riset Pengembangan Ilmu Pengetahuan dan Teknologi (IPTEK) FY 2016 scheme. We also thank Kapsulindo Nusantara, Inc. for supporting the production of nutraceutical hardshell carrageenan-based capsules.
Funding Information:
The authors thank the Ministry of Research, Technology and Higher Education, Indonesia for the research support fund through the Riset Pengembangan Ilmu Pengetahuan dan Teknologi (IPTEK) FY 2016 scheme. We also thank Kapsulindo Nusantara, Inc. for supporting the production of nutraceutical hardshell carrageenan-based capsules.
Publisher Copyright:
© 2020 Pratiwi Pudjiastuti et al., published by De Gruyter 2020.
PY - 2020/1/1
Y1 - 2020/1/1
N2 - The release of drugs from solid drug delivery materials has been studied intently in recent years. Quantitative analyses achieved from in vitro dissolution becomes easier if a zero-order mathematical model is used. Non-gelatin nutraceutical hard-shell capsules of zero size (approximately 0.7-0.8 cm) were produced from carrageenan-based natural polymers, namely carrageenan-alginate (CA) and carrageenan-starch (CS). Disintegration, dissolution and zero-order drug release kinetics of hard-shell capsules containing 100 mg of salicylamide were studied. The disintegration time of CA and CS were observed to be less than 30 min for both CA and CS. In vitro dissolution profile showed that the percentage dissolution of CA capsules was better at pH 4.5, while that of CS was poor at pH 1.2, 4.5 and 6.8. Determination of drug release kinetics profiles of carrageenan-based hardshell capsules utilized the Noyes-Whitney and Peppas-Sahlin modification rules for zero-order. The drug release from carrageenan-based capsules followed zero-order kinetics, especially at pH 6.8, and was compared to the Higuchi model. Salicylamide in CA hard-shell capsules at a pH 6.8 had a release rate constant (kH) of 2.91 %(ppm/ ppm) min-1/2, while the release rate constant of CS was 0.36
AB - The release of drugs from solid drug delivery materials has been studied intently in recent years. Quantitative analyses achieved from in vitro dissolution becomes easier if a zero-order mathematical model is used. Non-gelatin nutraceutical hard-shell capsules of zero size (approximately 0.7-0.8 cm) were produced from carrageenan-based natural polymers, namely carrageenan-alginate (CA) and carrageenan-starch (CS). Disintegration, dissolution and zero-order drug release kinetics of hard-shell capsules containing 100 mg of salicylamide were studied. The disintegration time of CA and CS were observed to be less than 30 min for both CA and CS. In vitro dissolution profile showed that the percentage dissolution of CA capsules was better at pH 4.5, while that of CS was poor at pH 1.2, 4.5 and 6.8. Determination of drug release kinetics profiles of carrageenan-based hardshell capsules utilized the Noyes-Whitney and Peppas-Sahlin modification rules for zero-order. The drug release from carrageenan-based capsules followed zero-order kinetics, especially at pH 6.8, and was compared to the Higuchi model. Salicylamide in CA hard-shell capsules at a pH 6.8 had a release rate constant (kH) of 2.91 %(ppm/ ppm) min-1/2, while the release rate constant of CS was 0.36
KW - Capsule
KW - Dissolution
KW - Drug release kinetics
KW - Salicylamide
KW - k-Carrageenan
UR - http://www.scopus.com/inward/record.url?scp=85083653827&partnerID=8YFLogxK
U2 - 10.1515/chem-2020-0028
DO - 10.1515/chem-2020-0028
M3 - Article
AN - SCOPUS:85083653827
SN - 2391-5420
VL - 18
SP - 226
EP - 231
JO - Open Chemistry
JF - Open Chemistry
IS - 1
ER -