TY - JOUR
T1 - Discovery of super–insecticide-resistant dengue mosquitoes in Asia
T2 - Threats of concomitant knockdown resistance mutations
AU - Kasai, Shinji
AU - Itokawa, Kentaro
AU - Uemura, Nozomi
AU - Takaoka, Aki
AU - Furutani, Shogo
AU - Maekawa, Yoshihide
AU - Kobayashi, Daisuke
AU - Imanishi-Kobayashi, Nozomi
AU - Amoa-Bosompem, Michael
AU - Murota, Katsunori
AU - Higa, Yukiko
AU - Kawada, Hitoshi
AU - Minakawa, Noboru
AU - Cuong, Tran Chi
AU - Yen, Nguyen Thi
AU - Phong, Tran Vu
AU - Keo, Sath
AU - Kang, Kroesna
AU - Miura, Kozue
AU - Ng, Lee Ching
AU - Teng, Hwa Jen
AU - Dadzie, Samuel
AU - Subekti, Sri
AU - Mulyatno, Kris Cahyo
AU - Sawabe, Kyoko
AU - Tomita, Takashi
AU - Komagata, Osamu
N1 - Funding Information:
We thank T. Tsunoda for support in mosquito collection. We are also grateful to C. Yoshida for technical assistance in mosquito maintenance. This study was supported by the Japan Agency for Medical Research and Development (AMED) JP17fm0108018, JP20fk0108067, JP20wm0225007, JP21wm0125006, JP21wm0225007, and JP21fk0108613.
Publisher Copyright:
Copyright © 2022 The Authors, some rights reserved.
PY - 2022/12
Y1 - 2022/12
N2 - Aedes aegypti (Linnaeus, 1762) is the main mosquito vector for dengue and other arboviral infectious diseases. Control of this important vector highly relies on the use of insecticides, especially pyrethroids. The high frequency (>78%) of the L982W substitution was detected at the target site of the pyrethroid insecticide, the voltage-gated sodium channel (Vgsc) of A. aegypti collected from Vietnam and Cambodia. Alleles having concomitant mutations L982W + F1534C and V1016G + F1534C were also confirmed in both countries, and their frequency was high (>90%) in Phnom Penh, Cambodia. Strains having these alleles exhibited substantially higher levels of pyrethroid resistance than any other field population ever reported. The L982W substitution has never been detected in any country of the Indochina Peninsula except Vietnam and Cambodia, but it may be spreading to other areas of Asia, which can cause an unprecedentedly serious threat to the control of dengue fever as well as other Aedes-borne infectious diseases.
AB - Aedes aegypti (Linnaeus, 1762) is the main mosquito vector for dengue and other arboviral infectious diseases. Control of this important vector highly relies on the use of insecticides, especially pyrethroids. The high frequency (>78%) of the L982W substitution was detected at the target site of the pyrethroid insecticide, the voltage-gated sodium channel (Vgsc) of A. aegypti collected from Vietnam and Cambodia. Alleles having concomitant mutations L982W + F1534C and V1016G + F1534C were also confirmed in both countries, and their frequency was high (>90%) in Phnom Penh, Cambodia. Strains having these alleles exhibited substantially higher levels of pyrethroid resistance than any other field population ever reported. The L982W substitution has never been detected in any country of the Indochina Peninsula except Vietnam and Cambodia, but it may be spreading to other areas of Asia, which can cause an unprecedentedly serious threat to the control of dengue fever as well as other Aedes-borne infectious diseases.
UR - http://www.scopus.com/inward/record.url?scp=85144593112&partnerID=8YFLogxK
U2 - 10.1126/sciadv.abq7345
DO - 10.1126/sciadv.abq7345
M3 - Article
C2 - 36542722
AN - SCOPUS:85144593112
SN - 2375-2548
VL - 8
JO - Science advances
JF - Science advances
IS - 51
M1 - eabq7345
ER -
