Dihydrostilbenes from Macaranga javanica (Blume) Müll. Arg. and their antiplasmodial activity

Tjitjik Srie Tjahjandarie, Muhammad Fajar Aldin, Ratih Dewi Saputri, Mulyadi Tanjung

Research output: Contribution to journalArticlepeer-review

Abstract

An undescribed dihydrostilbene, macajavanicin D (1), and three known analogs, malayheyneiin A (2) and laevifolins A-B (3-4), were isolated from Macaranga javanica (Blume) Müll. Arg. leaves. Macajavanicin D (1) structure was determined based on a combination of ESI-HRMS data and NMR spectra. Compounds 1-4 were evaluated to Plasmodium falciparum strain 3D7. Macajavanicins D (1) and laevifolin A (3) showed potent activity with an IC50 value of 0.85 and 1.03 µg/mL, respectively.

Original languageEnglish
JournalNatural Product Research
DOIs
Publication statusAccepted/In press - 2024

Keywords

  • antiplasmodial
  • dihydrostilbene
  • Macajavanicin D
  • Macaranga javanica

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