Dihydrostilbenes from Macaranga javanica (Blume) Müll. Arg. and their antiplasmodial activity

Tjitjik Srie Tjahjandarie; Muhammad Fajar Aldin; Ratih Dewi Saputri; Mulyadi Tanjung

doi:10.1080/14786419.2024.2342555

Dihydrostilbenes from Macaranga javanica (Blume) Müll. Arg. and their antiplasmodial activity

Tjitjik Srie Tjahjandarie, Muhammad Fajar Aldin, Ratih Dewi Saputri, Mulyadi Tanjung

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

An undescribed dihydrostilbene, macajavanicin D (1), and three known analogs, malayheyneiin A (2) and laevifolins A-B (3-4), were isolated from Macaranga javanica (Blume) Müll. Arg. leaves. Macajavanicin D (1) structure was determined based on a combination of ESI-HRMS data and NMR spectra. Compounds 1-4 were evaluated to Plasmodium falciparum strain 3D7. Macajavanicins D (1) and laevifolin A (3) showed potent activity with an IC₅₀ value of 0.85 and 1.03 µg/mL, respectively.

Original language	English
Journal	Natural Product Research
DOIs	https://doi.org/10.1080/14786419.2024.2342555
Publication status	Accepted/In press - 2024

Keywords

Macajavanicin D
Macaranga javanica
antiplasmodial
dihydrostilbene

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10.1080/14786419.2024.2342555

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title = "Dihydrostilbenes from Macaranga javanica (Blume) M{\"u}ll. Arg. and their antiplasmodial activity",

abstract = "An undescribed dihydrostilbene, macajavanicin D (1), and three known analogs, malayheyneiin A (2) and laevifolins A-B (3-4), were isolated from Macaranga javanica (Blume) M{\"u}ll. Arg. leaves. Macajavanicin D (1) structure was determined based on a combination of ESI-HRMS data and NMR spectra. Compounds 1-4 were evaluated to Plasmodium falciparum strain 3D7. Macajavanicins D (1) and laevifolin A (3) showed potent activity with an IC50 value of 0.85 and 1.03 µg/mL, respectively.",

keywords = "Macajavanicin D, Macaranga javanica, antiplasmodial, dihydrostilbene",

author = "Tjahjandarie, {Tjitjik Srie} and Aldin, {Muhammad Fajar} and Saputri, {Ratih Dewi} and Mulyadi Tanjung",

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year = "2024",

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language = "English",

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AU - Tjahjandarie, Tjitjik Srie

AU - Aldin, Muhammad Fajar

AU - Saputri, Ratih Dewi

AU - Tanjung, Mulyadi

PY - 2024

Y1 - 2024

N2 - An undescribed dihydrostilbene, macajavanicin D (1), and three known analogs, malayheyneiin A (2) and laevifolins A-B (3-4), were isolated from Macaranga javanica (Blume) Müll. Arg. leaves. Macajavanicin D (1) structure was determined based on a combination of ESI-HRMS data and NMR spectra. Compounds 1-4 were evaluated to Plasmodium falciparum strain 3D7. Macajavanicins D (1) and laevifolin A (3) showed potent activity with an IC50 value of 0.85 and 1.03 µg/mL, respectively.

AB - An undescribed dihydrostilbene, macajavanicin D (1), and three known analogs, malayheyneiin A (2) and laevifolins A-B (3-4), were isolated from Macaranga javanica (Blume) Müll. Arg. leaves. Macajavanicin D (1) structure was determined based on a combination of ESI-HRMS data and NMR spectra. Compounds 1-4 were evaluated to Plasmodium falciparum strain 3D7. Macajavanicins D (1) and laevifolin A (3) showed potent activity with an IC50 value of 0.85 and 1.03 µg/mL, respectively.

KW - Macajavanicin D

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KW - antiplasmodial

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DO - 10.1080/14786419.2024.2342555

M3 - Article

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SN - 1478-6419

JO - Natural Product Research

JF - Natural Product Research

ER -

Dihydrostilbenes from Macaranga javanica (Blume) Müll. Arg. and their antiplasmodial activity

Abstract

Keywords

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