TY - JOUR
T1 - Dihydroflavonols from the leaves of Macaranga recurvata and their cytotoxic and antioxidant activities
AU - Tanjung, Mulyadi
AU - Tjitjik, Srie Tjahjandarie
N1 - Publisher Copyright:
© 2014, Journal of Chemical and Pharmaceutical Research. All rights reserved.
PY - 2014
Y1 - 2014
N2 - Three dihydroflavonol derivatives, macarecurvatin A (1), macarecurvatin B (2), and 6,8-diisoprenylaromadendrin (3) have been isolated from the leaves of Macaranga recurvata. The structures of these compounds were determined based on UV, IR, HRESIMS, 1D and 2D NMR data. All of compound isolated were evaluated for their inhibitory effect on scavenging DPPH radical and their growth inhibition on MCF7, and tamoxifen-resistant MCF7 (MCF7/TAMR) breast cancer cell showed high antioxidant and high cytotoxic activities.
AB - Three dihydroflavonol derivatives, macarecurvatin A (1), macarecurvatin B (2), and 6,8-diisoprenylaromadendrin (3) have been isolated from the leaves of Macaranga recurvata. The structures of these compounds were determined based on UV, IR, HRESIMS, 1D and 2D NMR data. All of compound isolated were evaluated for their inhibitory effect on scavenging DPPH radical and their growth inhibition on MCF7, and tamoxifen-resistant MCF7 (MCF7/TAMR) breast cancer cell showed high antioxidant and high cytotoxic activities.
KW - 6, 8-Diisoprenylaromadendrin
KW - Antioxidant
KW - Cytotoxic
KW - Dihyroflavonol
KW - Macaranga recurvata
KW - Macarecurvatin A and B
UR - http://www.scopus.com/inward/record.url?scp=84907242819&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:84907242819
SN - 0975-7384
VL - 6
SP - 90
EP - 95
JO - Journal of Chemical and Pharmaceutical Research
JF - Journal of Chemical and Pharmaceutical Research
IS - 7
ER -
