Dihydroflavonols from the leaves of Macaranga recurvata and their cytotoxic and antioxidant activities

Mulyadi Tanjung, Srie Tjahjandarie Tjitjik

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

Three dihydroflavonol derivatives, macarecurvatin A (1), macarecurvatin B (2), and 6,8-diisoprenylaromadendrin (3) have been isolated from the leaves of Macaranga recurvata. The structures of these compounds were determined based on UV, IR, HRESIMS, 1D and 2D NMR data. All of compound isolated were evaluated for their inhibitory effect on scavenging DPPH radical and their growth inhibition on MCF7, and tamoxifen-resistant MCF7 (MCF7/TAMR) breast cancer cell showed high antioxidant and high cytotoxic activities.

Original languageEnglish
Pages (from-to)90-95
Number of pages6
JournalJournal of Chemical and Pharmaceutical Research
Volume6
Issue number7
Publication statusPublished - 2014

Keywords

  • 6, 8-Diisoprenylaromadendrin
  • Antioxidant
  • Cytotoxic
  • Dihyroflavonol
  • Macaranga recurvata
  • Macarecurvatin A and B

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