Differential Expression of IL-6 Following Topical Administration of the Probiotic Lactobacillus Casei Shirota in the Healing of Traumatic Ulcers in Wistar Rats (Rattus Novergicus)

Traumatic ulcers are one of the most common mucosal diseases. Ulcerated surfaces are commonly formed as a result of injuries involving the soft tissues of the oral cavity. Injuries can occur as a result of events such as accidentally biting oneself while speaking or sleeping. The goal of this study was to see if there were any variations in IL-6 expression after Wistar rats were treated topically with the probiotic Lactobacillus casei Shirota to treat traumatic ulcers. Research methods24 healthy male Wistar rats weighing 175-250 grams and aged 2-3 months were used in this experimental laboratory study. The labial portion of the fornix incisive inferior was polished using a hot round burnisher to produce traumatic ulcers. (n = 6) Six example groups are present. Distilled water was given to the control group over 3 days and 7 days at a rate of 20 liters per kilogram of body weight. Probiotics were applied topically to the afflicted areas for the topical groups for 3 days and 7 days at a rate of 10.9 × 107 cells per kilogram of body weight. Immunohistochemistry was used to detect IL-6 expression. According to the Post Hoc test, there was a significant difference in IL-6 expression between the 3-day topical group and the 3-day control group (p = 0.000). The levels of IL-6 expression were significantly different between the 7-day topical group and the 7-day control group (p = 0.000). Topical probiotic therapy reduces IL-6 expression and accelerates the inflammatory phase in the healing process of traumatic ulcers in Wistar rats (Rattus novergicus).