TY - JOUR
T1 - Differences in interleukin-6 and interleukin-17 expression in covid-19 post-mortem lung tissue biopsy compared with noncovid- 19
AU - Kusumastuti, Etty Hary
AU - Wiratama, Priangga Adi
AU - Ariani, Grace
AU - Djuanda, Stephanie Natasha
AU - Rahniayu, Alphania
AU - Kurniasari, Nila
AU - Fauziah, Dyah
AU - Rahaju, Anny Setijo
AU - Marhana, Isnin Anang
AU - Rosyid, Alfian Nur
AU - Wahyu, Dwi
AU - Nugroho, Gilang Muhammad Setyo
AU - Anggoro, Adhitri
AU - Yandi, I. Komang Rusgi
AU - Semedi, Bambang Pujo
AU - Lilihata, Jilientasia Godrace
AU - Maimunah, Ummi
AU - Supriadi,
AU - Lefi, Achmad
AU - Rinjani, Lalu Galih Pratama
AU - Suyanto, Edi
AU - Nugraha, Ricardo Ardian
N1 - Funding Information:
The authors are grateful for support from the director and research and development unit Dr. Soetomo General Academic Hospital.
Publisher Copyright:
© 2022 Phcogj.Com.
PY - 2022/11/1
Y1 - 2022/11/1
N2 - Background: COVID-19 has spread rapidly around the world. It is necessary to study lung tissue of postmortem COVID19 patients to determine the molecular alteration particularly the role of IL-6 and IL-17 in causing fatality. Objective: This study aims to determine the differences in the expressions of IL-6 and IL-17 in lung tissue of post-mortem COVID-19 patients compared to non-COVID-19 patients. This study also aimed to analyze the correlation between the expressions of IL-6 and IL-17 in lung tissue of post-mortem COVID-19 patients. Methods: This research is an observational analytic study with crosssectional approach. The samples were 15 paraffin blocks of post-mortem lung tissue biopsy of COVID-19 patients, and 15 paraffin blocks of inflammatory lung tissue biopsy or surgery of non-COVID-19 patients. IL-6 and IL-17 expressions were evaluated by immunohistochemical procedure. Result: There was a significant difference in the expression of IL-6 in the COVID-19 group and the non-COVID-19 group with a p-value = 0.001 (p < 0.05). There was a significant difference in the expression of IL-17 in the COVID-19 group and the non-COVID-19 group with p-value = 0.001 (p < 0.05). There was a significant correlation between the expressions of IL-6 and IL-17 in the COVID-19 group, with the Spearman coefficient value (rs) of 0.548 with p = 0.034 (p < 0.05). Conclusion: There are differences in the expression of IL-6 and IL-17 between COVID-19 and non-COVID-19 lung tissue. There is a significant correlation between the expressions of IL-6 and IL-17 in post-mortem lung tissue of COVID-19 patients.
AB - Background: COVID-19 has spread rapidly around the world. It is necessary to study lung tissue of postmortem COVID19 patients to determine the molecular alteration particularly the role of IL-6 and IL-17 in causing fatality. Objective: This study aims to determine the differences in the expressions of IL-6 and IL-17 in lung tissue of post-mortem COVID-19 patients compared to non-COVID-19 patients. This study also aimed to analyze the correlation between the expressions of IL-6 and IL-17 in lung tissue of post-mortem COVID-19 patients. Methods: This research is an observational analytic study with crosssectional approach. The samples were 15 paraffin blocks of post-mortem lung tissue biopsy of COVID-19 patients, and 15 paraffin blocks of inflammatory lung tissue biopsy or surgery of non-COVID-19 patients. IL-6 and IL-17 expressions were evaluated by immunohistochemical procedure. Result: There was a significant difference in the expression of IL-6 in the COVID-19 group and the non-COVID-19 group with a p-value = 0.001 (p < 0.05). There was a significant difference in the expression of IL-17 in the COVID-19 group and the non-COVID-19 group with p-value = 0.001 (p < 0.05). There was a significant correlation between the expressions of IL-6 and IL-17 in the COVID-19 group, with the Spearman coefficient value (rs) of 0.548 with p = 0.034 (p < 0.05). Conclusion: There are differences in the expression of IL-6 and IL-17 between COVID-19 and non-COVID-19 lung tissue. There is a significant correlation between the expressions of IL-6 and IL-17 in post-mortem lung tissue of COVID-19 patients.
KW - Biopsy
KW - COVID-19
KW - IL-17
KW - IL-6
KW - Post mortem lung tissue
UR - http://www.scopus.com/inward/record.url?scp=85159887155&partnerID=8YFLogxK
U2 - 10.5530/pj.2022.14.184
DO - 10.5530/pj.2022.14.184
M3 - Article
AN - SCOPUS:85159887155
SN - 0975-3575
VL - 14
SP - 887
EP - 892
JO - Pharmacognosy Journal
JF - Pharmacognosy Journal
IS - 6
ER -