Development of Ofloxacin Electrochemical Sensor in Milk Sample using Boron-doped Diamond Electrode Decorated by Zinc Nanoparticles

The study of Ofloxacin (OFL) electrochemical sensor on the surface of zinc modified boron-doped diamond (Zn-BDD) electrode is reported. OFL has been known as one of the fluoroquinolone antibiotics which is used in treating infectious diseases and also in animal agriculture. Despite its effectiveness, long-term consumption could promote antimicrobial resistance. Therefore, a sensitive and selective detection method is important. Meanwhile, BDD has been known for its low background current and high stability, in which, it is necessary for sensor application. Besides, Zn nanoparticles have been widely used for sensor applications due to their low toxicity and low cost. In this work, Zn-BDD electrode was prepared through electrodeposition. The S/B value and sensitivity for OFL analysis were 9.5 and 0.42 respectively on Zn-BDD, in which, it is higher compared to the use of a bare BDD electrode. The analysis in milk was possible with the recovery of 83.05% and 101.20% for BDD and Zn-BDD electrodes respectively. It is suggested that Zn-BDD electrode could be applied for OFL analysis for further real application.