Development of electrode carbon paste modified by molecularly imprinted polymer as sensor for analysis of creatinine by potentiometric

This research aims to develop an electrode carbon paste/molecularly imprinted polymer (MIP) as a sensor for the analysis of creatinine by potentiometric. The preparation of a non-imprinted polymer (NIP) is done by mixing aniline, creatinine, and potassium peroxodisulfate with mole ratio of 2:0.1:1. Creatinine is extracted from the polymer using hot water to form mold creatinine, this so-called MIP. In this study, the optimum electrode has a composition made of activated carbon, paraffin, and MIP of 40:35:25 (mass ratio), pH of working solution 6, and response time of 91–192 s. The Nernst factor obtained from this study was 23.2 mV/decade, the measuring range of 10⁻⁶–10⁻³ M, lower detection limit of 5.49 × 10⁻⁶ M, and the upper detection limit of 1.07 × 10⁻³ M. The accuracy of methods for concentration of 10⁻⁶–10⁻³ M was 76.40–165.80%, and the precision expressed by the coefficient of variation for the concentration is 0.05–0.32%. The electrodes have up to 83 times of usage. Urea does not interfere with the performance of the electrode carbon paste MIP on the analysis of creatinine.