Determination, characterization and modeling of aqueous biphasic systems composed of propylammonium-based ionic liquids and phosphate salts

Cassamo U. Mussagy, Naiara L. Tabanez, Fabiane O. Farias, Kiki A. Kurnia, Marcos R. Mafra, Jorge F.B. Pereira

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)

Abstract

Ionic liquids (ILs)-based aqueous biphasic systems (ABS) are efficient platforms for the extraction and purification of biomolecules. To find more biocompatible ABS, propylammonium-based ILs, phosphate salts and water were mixed at three temperatures, evaluating the influence of IL and temperature on the liquid-liquid equilibria (LLE). The biphasic region increases with the increase of IL’ anionic/cationic chain and decreases with the increase of temperature. There is good agreement between the IL’ ability to form ABS and the hydrogen bonding interaction predicted by COSMO-RS. The subtle balance of hydrogen bonding between salt anion-water and IL anion-water governs the phase separation.

Original languageEnglish
Article number137623
JournalChemical Physics Letters
Volume754
DOIs
Publication statusPublished - Sept 2020

Keywords

  • Aqueous biphasic systems
  • COSMO-RS
  • Ionic liquids
  • Liquid-liquid extraction
  • NRTL
  • Phase diagrams

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