Abstract
Ionic liquids (ILs)-based aqueous biphasic systems (ABS) are efficient platforms for the extraction and purification of biomolecules. To find more biocompatible ABS, propylammonium-based ILs, phosphate salts and water were mixed at three temperatures, evaluating the influence of IL and temperature on the liquid-liquid equilibria (LLE). The biphasic region increases with the increase of IL’ anionic/cationic chain and decreases with the increase of temperature. There is good agreement between the IL’ ability to form ABS and the hydrogen bonding interaction predicted by COSMO-RS. The subtle balance of hydrogen bonding between salt anion-water and IL anion-water governs the phase separation.
Original language | English |
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Article number | 137623 |
Journal | Chemical Physics Letters |
Volume | 754 |
DOIs | |
Publication status | Published - Sept 2020 |
Keywords
- Aqueous biphasic systems
- COSMO-RS
- Ionic liquids
- Liquid-liquid extraction
- NRTL
- Phase diagrams