Detection of highly prevalent hepatitis B virus co-infection with HIV in Indonesia

Takako Utsumi; Yoshihiko Yano; Maria I. Lusida; Mochamad Amin; Hak Hotta; Yoshitake Hayashi

doi:10.1111/hepr.12053

Detection of highly prevalent hepatitis B virus co-infection with HIV in Indonesia

Takako Utsumi, Yoshihiko Yano, Maria I. Lusida, Nasronudin, Mochamad Amin, Juniastuti, Soetjipto, Hak Hotta, Yoshitake Hayashi

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

Aim: The prevalence of hepatitis B virus (HBV) co-infection with HIV is increasing worldwide because of shared transmission routes. This study aimed to assess the prevalence of HBV and HIV co-infection in Indonesia, and its molecular and clinical characteristics. Methods: A total of 118 serum samples from HIV-infected patients (age 33.3±8.9 years, 99 male, 19 female) collected in 2009 were serologically examined. HBV DNA was assessed by polymerase chain reaction (PCR) analysis targeting the S region. Results: Overall, 15.3% (18/118) of the patients were hepatitis B surface antigen (HBsAg) positive, whereas 27.1% (32/118) were HBsAg negative but HBV DNA positive, and were considered to have occult HBV infection. HBsAg antibodies and/or HBV core antibodies were detected in 45.6% (31/68) of HBV DNA negative patients. Conclusion: HBV co-infection, including occult HBV infection, was common in Indonesian HIV patients. Hepatic damage by the interaction of host immunity and HBV is still a remaining issue in these immunosuppressive patients, and further study will be needed.

Original language	English
Pages (from-to)	1032-1039
Number of pages	8
Journal	Hepatology Research
Volume	43
Issue number	10
DOIs	https://doi.org/10.1111/hepr.12053
Publication status	Published - Oct 2013

Keywords

Co-infection
HIV
Hepatitis B virus
Indonesia

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/hepr.12053

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title = "Detection of highly prevalent hepatitis B virus co-infection with HIV in Indonesia",

abstract = "Aim: The prevalence of hepatitis B virus (HBV) co-infection with HIV is increasing worldwide because of shared transmission routes. This study aimed to assess the prevalence of HBV and HIV co-infection in Indonesia, and its molecular and clinical characteristics. Methods: A total of 118 serum samples from HIV-infected patients (age 33.3±8.9 years, 99 male, 19 female) collected in 2009 were serologically examined. HBV DNA was assessed by polymerase chain reaction (PCR) analysis targeting the S region. Results: Overall, 15.3% (18/118) of the patients were hepatitis B surface antigen (HBsAg) positive, whereas 27.1% (32/118) were HBsAg negative but HBV DNA positive, and were considered to have occult HBV infection. HBsAg antibodies and/or HBV core antibodies were detected in 45.6% (31/68) of HBV DNA negative patients. Conclusion: HBV co-infection, including occult HBV infection, was common in Indonesian HIV patients. Hepatic damage by the interaction of host immunity and HBV is still a remaining issue in these immunosuppressive patients, and further study will be needed.",

keywords = "Co-infection, HIV, Hepatitis B virus, Indonesia",

author = "Takako Utsumi and Yoshihiko Yano and Lusida, {Maria I.} and Nasronudin and Mochamad Amin and Juniastuti and Soetjipto and Hak Hotta and Yoshitake Hayashi",

year = "2013",

month = oct,

doi = "10.1111/hepr.12053",

language = "English",

volume = "43",

pages = "1032--1039",

journal = "Hepatology Research",

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T1 - Detection of highly prevalent hepatitis B virus co-infection with HIV in Indonesia

AU - Utsumi, Takako

AU - Yano, Yoshihiko

AU - Lusida, Maria I.

AU - Nasronudin,

AU - Amin, Mochamad

AU - Juniastuti,

AU - Soetjipto,

AU - Hotta, Hak

AU - Hayashi, Yoshitake

PY - 2013/10

Y1 - 2013/10

N2 - Aim: The prevalence of hepatitis B virus (HBV) co-infection with HIV is increasing worldwide because of shared transmission routes. This study aimed to assess the prevalence of HBV and HIV co-infection in Indonesia, and its molecular and clinical characteristics. Methods: A total of 118 serum samples from HIV-infected patients (age 33.3±8.9 years, 99 male, 19 female) collected in 2009 were serologically examined. HBV DNA was assessed by polymerase chain reaction (PCR) analysis targeting the S region. Results: Overall, 15.3% (18/118) of the patients were hepatitis B surface antigen (HBsAg) positive, whereas 27.1% (32/118) were HBsAg negative but HBV DNA positive, and were considered to have occult HBV infection. HBsAg antibodies and/or HBV core antibodies were detected in 45.6% (31/68) of HBV DNA negative patients. Conclusion: HBV co-infection, including occult HBV infection, was common in Indonesian HIV patients. Hepatic damage by the interaction of host immunity and HBV is still a remaining issue in these immunosuppressive patients, and further study will be needed.

AB - Aim: The prevalence of hepatitis B virus (HBV) co-infection with HIV is increasing worldwide because of shared transmission routes. This study aimed to assess the prevalence of HBV and HIV co-infection in Indonesia, and its molecular and clinical characteristics. Methods: A total of 118 serum samples from HIV-infected patients (age 33.3±8.9 years, 99 male, 19 female) collected in 2009 were serologically examined. HBV DNA was assessed by polymerase chain reaction (PCR) analysis targeting the S region. Results: Overall, 15.3% (18/118) of the patients were hepatitis B surface antigen (HBsAg) positive, whereas 27.1% (32/118) were HBsAg negative but HBV DNA positive, and were considered to have occult HBV infection. HBsAg antibodies and/or HBV core antibodies were detected in 45.6% (31/68) of HBV DNA negative patients. Conclusion: HBV co-infection, including occult HBV infection, was common in Indonesian HIV patients. Hepatic damage by the interaction of host immunity and HBV is still a remaining issue in these immunosuppressive patients, and further study will be needed.

KW - Co-infection

KW - HIV

KW - Hepatitis B virus

KW - Indonesia

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DO - 10.1111/hepr.12053

M3 - Article

AN - SCOPUS:84885065190

SN - 1386-6346

VL - 43

SP - 1032

EP - 1039

JO - Hepatology Research

JF - Hepatology Research

IS - 10

ER -

Detection of highly prevalent hepatitis B virus co-infection with HIV in Indonesia

Abstract

Keywords

UN SDGs

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