Design of cellulose acetate-collagen nanofiber and its in vitro assessment as wound dressing candidate

M. F. Dzikri; T. P. Armedya; S. Q. Khairunisa; S. C.W. Sakti; Y. Raharjo; W. Purnamasari; N. Nasronudin; M. Z. Fahmi

Design of cellulose acetate-collagen nanofiber and its in vitro assessment as wound dressing candidate

M. F. Dzikri, T. P. Armedya, S. Q. Khairunisa, S. C.W. Sakti, Y. Raharjo, W. Purnamasari, N. Nasronudin, M. Z. Fahmi

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

In this study, we developed nanofiber composite membrane of cellulose acetate and collagen via electrospinning. Several variations on electrospinning process such as time, flow rate and collector optimizations have been done. The result showed that the optimum conditions were reached with flow rate at 0.05 µL/h using a drum or cylinder-shaped collector and optimum time for membrane formation for 3 h. The results of the CA-collagen membrane performed good results with the modulus young 1,237 x10^-5 GPa. The entire membrane has elongation according to human skin so it can be used as a candidate for wound dressing. The MTT assay reveals that all membrane was non-toxic with viability all over 80%.

Original language	English
Pages (from-to)	203-212
Number of pages	10
Journal	Digest Journal of Nanomaterials and Biostructures
Volume	14
Issue number	1
Publication status	Published - 1 Jan 2019

Keywords

Cellulose acetate
Collagen
Nanofiber membrane

Cite this

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title = "Design of cellulose acetate-collagen nanofiber and its in vitro assessment as wound dressing candidate",

abstract = "In this study, we developed nanofiber composite membrane of cellulose acetate and collagen via electrospinning. Several variations on electrospinning process such as time, flow rate and collector optimizations have been done. The result showed that the optimum conditions were reached with flow rate at 0.05 µL/h using a drum or cylinder-shaped collector and optimum time for membrane formation for 3 h. The results of the CA-collagen membrane performed good results with the modulus young 1,237 x10-5 GPa. The entire membrane has elongation according to human skin so it can be used as a candidate for wound dressing. The MTT assay reveals that all membrane was non-toxic with viability all over 80%.",

keywords = "Cellulose acetate, Collagen, Nanofiber membrane",

author = "Dzikri, {M. F.} and Armedya, {T. P.} and Khairunisa, {S. Q.} and Sakti, {S. C.W.} and Y. Raharjo and W. Purnamasari and N. Nasronudin and Fahmi, {M. Z.}",

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T1 - Design of cellulose acetate-collagen nanofiber and its in vitro assessment as wound dressing candidate

AU - Dzikri, M. F.

AU - Armedya, T. P.

AU - Khairunisa, S. Q.

AU - Sakti, S. C.W.

AU - Raharjo, Y.

AU - Purnamasari, W.

AU - Nasronudin, N.

AU - Fahmi, M. Z.

PY - 2019/1/1

Y1 - 2019/1/1

N2 - In this study, we developed nanofiber composite membrane of cellulose acetate and collagen via electrospinning. Several variations on electrospinning process such as time, flow rate and collector optimizations have been done. The result showed that the optimum conditions were reached with flow rate at 0.05 µL/h using a drum or cylinder-shaped collector and optimum time for membrane formation for 3 h. The results of the CA-collagen membrane performed good results with the modulus young 1,237 x10-5 GPa. The entire membrane has elongation according to human skin so it can be used as a candidate for wound dressing. The MTT assay reveals that all membrane was non-toxic with viability all over 80%.

AB - In this study, we developed nanofiber composite membrane of cellulose acetate and collagen via electrospinning. Several variations on electrospinning process such as time, flow rate and collector optimizations have been done. The result showed that the optimum conditions were reached with flow rate at 0.05 µL/h using a drum or cylinder-shaped collector and optimum time for membrane formation for 3 h. The results of the CA-collagen membrane performed good results with the modulus young 1,237 x10-5 GPa. The entire membrane has elongation according to human skin so it can be used as a candidate for wound dressing. The MTT assay reveals that all membrane was non-toxic with viability all over 80%.

KW - Cellulose acetate

KW - Collagen

KW - Nanofiber membrane

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JF - Digest Journal of Nanomaterials and Biostructures

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Design of cellulose acetate-collagen nanofiber and its in vitro assessment as wound dressing candidate

Abstract

Keywords

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