Dengue hemorrhagic fever in infants: Research opportunities ignored

Scott B. Halstead, Nguyen Trong Lan, Thein Thein Myint, Than Nu Shwe, Ananda Nisalak, Siripen Kalyanarooj, Suchitra Nimmannitya, Soegeng Soegijanto, David W. Vaughn, Timothy P. Endy

Research output: Contribution to journalReview articlepeer-review

202 Citations (Scopus)


The age distribution of cases of dengue hemorrhagic fever and dengue shock syndrome (DHF/DSS) in infants under the age of 1 year are reported from Bangkok, Thailand, and for the first time for Ho Chi Minh City, Vietnam; Yangon, Myanmar; and Surabaya, Indonesia. The four dengue viruses were isolated from Thai infants, all of whom were having a primary dengue infection. Progress studying the immunologically distinct infant DHF/DSS has been limited; most contemporary research has centered on DHF/DSS accompanying secondary dengue infections. In designing research results obtained in studies on a congruent animal model, feline infectious peritonitis virus (FIPV) infections of kittens born to FIPV-immune queens should be considered. Research challenges presented by infant DHF/DSS are discussed.

Original languageEnglish
Pages (from-to)1474-1479
Number of pages6
JournalEmerging Infectious Diseases
Issue number12
Publication statusPublished - 1 Dec 2002


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