Demineralized Dentin Material Sponge as a Guided Bone Regeneration

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1 Citation (Scopus)


Reconstruction of craniofacial bone defects due to trauma, infection or tumor resection is a major problem faced by professions in dentistry, oral and maxillofacial surgery, orthopedic surgery, oncology and neurosurgery. One of the treatments that can be done for cases of bone defects is using Guided Bone Regeneration (GBR). The objective of this study is to present an evaluation of literature regarding the rule of Deminalized Dentin Matrix Sponge (DDMS) as GBR. GBR procedure uses a membrane that acts as a physical barrier to invasion of connective cells and epithelial cells from the surrounding soft tissue, which also produces osteogenic cells, showing a slower migration rate, thus creating a situation conducive to bone regeneration. Deminalized Dentin Matrix (DDM) affects the release of growth factors in the type I collagen matrix which is usually involved in bone mineralization. This makes DDM more inductive than mineralized dentin. DDMS as a biomaterial has the potential for bone tissue engineering in terms of biophysics and biocompability, and has the potential to be used as Guided Bone Regeneration in bone tissue regeneration.

Original languageEnglish
Pages (from-to)98-101
Number of pages4
JournalMalaysian Journal of Medicine and Health Sciences
Publication statusPublished - Sept 2021


  • Bone
  • Dentin
  • Guided bone regeneration
  • Sponge
  • Tissue engineering


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