Deetion of twenty seven nucleotides within exon 11 of the band 3 gene indentified in ovalocytesis in Lombok Island, Indonesia

Haryanto Aumsardjono, Indri Safitri Mukono, Yoes Prijatna Dachlan, Masafumi Matsou

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

This study reports the molecular characterization of ovalocytosis in Lombok Island, Indonesia. The analysis of genomic DNA by polymerase chain reaction shows that all 21 ovalocytotic individuals have two amplified products of different size from a region encompassing exon 11 of the band 3 gene. The sequence of the larger product matched perfectly with that of normal individuals. In the sequence of the smaller product, 27 nucleotides within exon 11 were deleted. The heterozygous presence of the deletion identified in other parts of Southeast Asia was confirmed in patients with ovalocytosis in an isolated island of eastern Indonesia.

Original languageEnglish
Pages (from-to)233-236
Number of pages4
JournalJapanese Journal of Human Genetics
Volume42
Issue number1
Publication statusPublished - 1997

Keywords

  • Band 3
  • Deletion
  • Erythrocyte
  • Ovalocytosis

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