TY - JOUR
T1 - Deadly paraquat poisoning in a 7-years-old child
T2 - A case report
AU - Lazulfa, Indana
AU - Kusumastuti, Neurinda Permata
AU - Azis, Abdul Latief
AU - Dharmawati, Ira
AU - Setyaningsih, Arina
AU - Lestari, Dwi Putri
N1 - Publisher Copyright:
© 2024, Sami Publishing Company. All rights reserved.
PY - 2024/7
Y1 - 2024/7
N2 - Paraquat is an organic herbicide which is widely used as a weed killer. Paraquat intoxication is lethal since there is no specific antidote. To highlight the clinical appearance and increase awareness of paraquat intoxication in children. A seven-year-old boy experienced nausea and vomiting one hour after consuming dark liquid containing paraquat. Three days later, he complained of bloody vomiting, sore throat, and abdominal discomfort and was taken to a nearby hospital. He received gastric lavage four times and was treated conservatively with intravenous fluid and H2 blockers at the High Care Unit (HCU). The patient's condition deteriorated, leading to the development of acute hepatic failure and dark urine, and then referred to our tertiary hospital for further management. Laboratory examination showed anemia, thrombocytosis, and worsening renal and liver functions. Chest x-ray revealed pneumonitis. Steroid, intravenous acetylcysteine, and hepato-protector were given. However, he died after progressive type I respiratory failure on day 14 after the ingestion. Paraquat is a common herbicide with a high mortality on ingestion since the antidote has not been found to this day. Our patient, a seven-year-old boy, accidentally ingested the paraquat. He suffered from nausea and vomiting in one hour after ingestion. Sore throat, bloody stool, vomiting, and abdominal discomfort on day 3 and yellowish skin on day 5. Even though he got further treatment, he died on day 14 after the ingestion, due to type I respiratory failure.
AB - Paraquat is an organic herbicide which is widely used as a weed killer. Paraquat intoxication is lethal since there is no specific antidote. To highlight the clinical appearance and increase awareness of paraquat intoxication in children. A seven-year-old boy experienced nausea and vomiting one hour after consuming dark liquid containing paraquat. Three days later, he complained of bloody vomiting, sore throat, and abdominal discomfort and was taken to a nearby hospital. He received gastric lavage four times and was treated conservatively with intravenous fluid and H2 blockers at the High Care Unit (HCU). The patient's condition deteriorated, leading to the development of acute hepatic failure and dark urine, and then referred to our tertiary hospital for further management. Laboratory examination showed anemia, thrombocytosis, and worsening renal and liver functions. Chest x-ray revealed pneumonitis. Steroid, intravenous acetylcysteine, and hepato-protector were given. However, he died after progressive type I respiratory failure on day 14 after the ingestion. Paraquat is a common herbicide with a high mortality on ingestion since the antidote has not been found to this day. Our patient, a seven-year-old boy, accidentally ingested the paraquat. He suffered from nausea and vomiting in one hour after ingestion. Sore throat, bloody stool, vomiting, and abdominal discomfort on day 3 and yellowish skin on day 5. Even though he got further treatment, he died on day 14 after the ingestion, due to type I respiratory failure.
KW - Paraquat intoxication
KW - accidental case
KW - acetylcysteine
KW - antidote
KW - gramoxone
UR - http://www.scopus.com/inward/record.url?scp=85186851665&partnerID=8YFLogxK
U2 - 10.48309/jmpcr.2024.435284.1089
DO - 10.48309/jmpcr.2024.435284.1089
M3 - Article
AN - SCOPUS:85186851665
SN - 2981-0221
VL - 6
SP - 953
EP - 958
JO - Journal of Medicinal and Pharmaceutical Chemistry Research
JF - Journal of Medicinal and Pharmaceutical Chemistry Research
IS - 7
ER -