Daphne genkwa sieb. et zucc. as anticancer of oral squamous cell carcinoma: A systematic review

Oral squamous cell carcinoma (OSCC) is the most common type of oral malignant neoplasm. It is weird cancer incidence due to hardly to prognosis. Natural resources have been optional treatment to any kind of diseases, including cancer. Daphne genkwa is herbal plant that have been used as chinese traditional medicine and studied for a long time ago as illness treatment. The present sudy was performed anticancer properties of Daphne genkwa to OSCC. The qualitative systematic review were obtained from Google Scholar, Medline, PubMed, Research Gate and Scopus. Data selection criteria are followed with keywords such as Daphne genkwa, herbal plant, phytochemistry, oral squamous cell carcinoma, chemoteraphy, and anticancer drug. Daphne genkwa had anticancer activities through multiple mechanism inhibition of cellular movement, cell cycle arrest, and blocking cell proliferation in oral cancer cells. Daphne genkwa have capability to developed as a promising anticancer source for OSCC. More extensive research are needed as clinical trials to determine which active compound that have best results as anticancer candidate.