Düşük doğum tartılı bebeklerde enteral glutamin desteğinin kilo alma modelleri ve dışkıdaki salgısal immünoglubulin A düzeyleri üzerinde etkisi

Translated title of the contribution: Effect of enteral glutamine supplementation for low-birth-weight infants on weight gain patterns and levels of fecal secretory immunoglobulin A

Mahendra Sampurna, Dina Angelika, Martono Tri Utomo, Nur Aisiyah Wijaya, Budiono Budiono, Firas Farisi Alkaff, Roedi Irawan, Risa Etika

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Aim: Glutamine is needed for optimal cell growth and for the immune system, especially in the enterocytes of gut mucosal immune responses. Low birth weight makes infants susceptible to glutamine depletion because nutrition is limited in the first week of life. To determine the effect of enteral glutamine supplementation on weight gain patterns and fecal secretory immunoglobulin A. Material and Methods: This study is a double-blind, randomized controlled trial. Infants were randomly assigned to the glutamine group and placebo group. The glutamine group was supplemented with glutamine 400 mg/kg/day for 14 days, and placebo group received glucose 400 mg/kg/day for 14 days. The infants were observed for 30 days. Return-to-birth-weight, weight gain velocity, and fecal secretory immunoglobulin A levels were monitored during the study. Results: Thirty-seven low-birth-weight infants were randomly assigned to the glutamine and placebo groups. The glutamine group had a shorter return-to-birth-weight time than the placebo group (8.1±0.9 vs. 11.0±1.6 days) and faster weight gain velocity (20.0±1.8 vs. 15.5±2.2 g/kg/day) (p<0.001). Secretory immunoglobulin A levels after glutamine supplementation were higher than in the placebo group (0.456±0.057 vs. 0.376±0.035 mg/g) (p<0.001). Levels of secretory immunoglobulin A after treatment in each group were increased. However, there was a significant difference before and after supplementation between the glutamine and placebo groups (0.247±0.024 vs. 0.140±0.016 mg/g) (p<0.001). Conclusion: Enteral glutamine supplementation in low-birth-weight infants accelerates return to birth weight, increases the weight gain velocity, and the levels of fecal secretory immunoglobulin A.

Translated title of the contributionEffect of enteral glutamine supplementation for low-birth-weight infants on weight gain patterns and levels of fecal secretory immunoglobulin A
Original languageTurkish
Pages (from-to)231-237
Number of pages7
JournalTurk Pediatri Arsivi
Volume53
Issue number4
DOIs
Publication statusPublished - 2018

Keywords

  • Enteral glutamine supplementation
  • Fecal sIgA
  • Low birth weight
  • Weight gain pattern

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