Cytotoxicity evaluation of two new chalcones from the leaves of Flemingia macrophylla (Willd.) Merr

Tjitjik Srie Tjahjandarie; Mulyadi Tanjung; Ratih Dewi Saputri; Muhammad Fajar Aldin; Retno Ari Susanti; Nanda Putri Pertiwi; Rizaldy Satriya Wibawa; Ida Nur Halizah

doi:10.1016/j.phytol.2021.06.006

Cytotoxicity evaluation of two new chalcones from the leaves of Flemingia macrophylla (Willd.) Merr

Tjitjik Srie Tjahjandarie, Mulyadi Tanjung, Ratih Dewi Saputri, Muhammad Fajar Aldin, Retno Ari Susanti, Nanda Putri Pertiwi, Rizaldy Satriya Wibawa, Ida Nur Halizah

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

Two unreported chalcone derivatives: flemingins P and Q (1 and 2), and two known analogues (3 and 4) were isolated from the leaves of Flemingia macrophylla (Willd.)Merr.The structures of flemingins P and Q were determined by a combination of spectroscopic methods. Chalcones 1–4 were assayed in four cancer cells (4T1, T47D, HeLa, and WiDr). Flemingin Q (2) exhibited high cytotoxic activity against 4T1, T47D, and HeLa cells, whereas compound 3 showed high cytotoxicity against 4T1 and WiDr cells. Conversely, compounds 1 and 4 did not show any anticancer activity towards the four cancer cells examined.

Original language	English
Pages (from-to)	78-81
Number of pages	4
Journal	Phytochemistry Letters
Volume	44
DOIs	https://doi.org/10.1016/j.phytol.2021.06.006
Publication status	Published - Aug 2021

Keywords

Chalcone
Cytotoxicity
Flemingia macrophylla
Flemingins P–Q

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.phytol.2021.06.006

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@article{3d043666a02a46229dcaed0ce571c917,

title = "Cytotoxicity evaluation of two new chalcones from the leaves of Flemingia macrophylla (Willd.) Merr",

abstract = "Two unreported chalcone derivatives: flemingins P and Q (1 and 2), and two known analogues (3 and 4) were isolated from the leaves of Flemingia macrophylla (Willd.)Merr.The structures of flemingins P and Q were determined by a combination of spectroscopic methods. Chalcones 1–4 were assayed in four cancer cells (4T1, T47D, HeLa, and WiDr). Flemingin Q (2) exhibited high cytotoxic activity against 4T1, T47D, and HeLa cells, whereas compound 3 showed high cytotoxicity against 4T1 and WiDr cells. Conversely, compounds 1 and 4 did not show any anticancer activity towards the four cancer cells examined.",

keywords = "Chalcone, Cytotoxicity, Flemingia macrophylla, Flemingins P–Q",

author = "Tjahjandarie, {Tjitjik Srie} and Mulyadi Tanjung and Saputri, {Ratih Dewi} and Aldin, {Muhammad Fajar} and Susanti, {Retno Ari} and Pertiwi, {Nanda Putri} and Wibawa, {Rizaldy Satriya} and Halizah, {Ida Nur}",

note = "Funding Information: This research was financially supported by Universitas Airlangga, Surabaya, Indonesia ( PDUPT, 2020 , Tjitjik Srie Tjahjandarie). Publisher Copyright: {\textcopyright} 2021 Phytochemical Society of Europe",

year = "2021",

month = aug,

doi = "10.1016/j.phytol.2021.06.006",

language = "English",

volume = "44",

pages = "78--81",

journal = "Phytochemistry Letters",

issn = "1874-3900",

publisher = "Elsevier BV",

}

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T1 - Cytotoxicity evaluation of two new chalcones from the leaves of Flemingia macrophylla (Willd.) Merr

AU - Tjahjandarie, Tjitjik Srie

AU - Tanjung, Mulyadi

AU - Saputri, Ratih Dewi

AU - Aldin, Muhammad Fajar

AU - Susanti, Retno Ari

AU - Pertiwi, Nanda Putri

AU - Wibawa, Rizaldy Satriya

AU - Halizah, Ida Nur

N1 - Funding Information: This research was financially supported by Universitas Airlangga, Surabaya, Indonesia ( PDUPT, 2020 , Tjitjik Srie Tjahjandarie). Publisher Copyright: © 2021 Phytochemical Society of Europe

PY - 2021/8

Y1 - 2021/8

N2 - Two unreported chalcone derivatives: flemingins P and Q (1 and 2), and two known analogues (3 and 4) were isolated from the leaves of Flemingia macrophylla (Willd.)Merr.The structures of flemingins P and Q were determined by a combination of spectroscopic methods. Chalcones 1–4 were assayed in four cancer cells (4T1, T47D, HeLa, and WiDr). Flemingin Q (2) exhibited high cytotoxic activity against 4T1, T47D, and HeLa cells, whereas compound 3 showed high cytotoxicity against 4T1 and WiDr cells. Conversely, compounds 1 and 4 did not show any anticancer activity towards the four cancer cells examined.

AB - Two unreported chalcone derivatives: flemingins P and Q (1 and 2), and two known analogues (3 and 4) were isolated from the leaves of Flemingia macrophylla (Willd.)Merr.The structures of flemingins P and Q were determined by a combination of spectroscopic methods. Chalcones 1–4 were assayed in four cancer cells (4T1, T47D, HeLa, and WiDr). Flemingin Q (2) exhibited high cytotoxic activity against 4T1, T47D, and HeLa cells, whereas compound 3 showed high cytotoxicity against 4T1 and WiDr cells. Conversely, compounds 1 and 4 did not show any anticancer activity towards the four cancer cells examined.

KW - Chalcone

KW - Cytotoxicity

KW - Flemingia macrophylla

KW - Flemingins P–Q

UR - http://www.scopus.com/inward/record.url?scp=85107702384&partnerID=8YFLogxK

U2 - 10.1016/j.phytol.2021.06.006

DO - 10.1016/j.phytol.2021.06.006

M3 - Article

AN - SCOPUS:85107702384

SN - 1874-3900

VL - 44

SP - 78

EP - 81

JO - Phytochemistry Letters

JF - Phytochemistry Letters

ER -

Cytotoxicity evaluation of two new chalcones from the leaves of Flemingia macrophylla (Willd.) Merr

Abstract

Keywords

UN SDGs

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