TY - JOUR
T1 - Cytotoxicity effect of the pericarp extracts of garcinia forbesii king on MCF-7 breast cancer and HepG2 liver cancer cell lines
AU - Joharman,
AU - Poerwono, Hadi
AU - Sukardiman,
N1 - Funding Information:
We are thankful to the Indonesian Ministry of Research, Technology and Higher Education, for the financial support for our research. We also thank the analyst of the Parasitology Laboratory, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, for the assistance in cytotoxicity assay.
Publisher Copyright:
© 2021 Phcogj.Com. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.
PY - 2021/1
Y1 - 2021/1
N2 - Background: The species from the genus Garcinia has long been used as traditional medicine for cancer treatment. Objective: To analyze the phytochemical contents and assess the cytotoxic effects of pericarp extracts of Garcinia forbesii King against MCF-7 breast cancer cells and HepG2 liver cancer cells. Materials and Methods: The phytochemical contents were analyzed using the thin-layer chromatography and the cytotoxic activity was assessed using the MTT assay method. Results: Phytochemical screening showed the presence of alkaloids, flavonoids, terpenoids and polyphenols. The cytotoxic activities of n-hexane, DCM and ethyl acetate extracts on MCF-7 cells were shown with IC50 103.605±2.3410 μg/ mL, 397.609±28.0534 μg/mL and 1,518.301±68.6379 μg/mL respectively, while the IC50 on HepG2 cells were 79.798±1.2261 μg/mL, 83.230±4.2557 μg/mL and 671.875±94.3338 μg/mL respectively. Conclusion: The n-hexane, DCM and ethyl acetate extracts from pericarps of G. forbesii King have cytotoxic activities against MCF-7 and HepG2 cancer cells, therefore, it has the potential to be developed as an anticancer.
AB - Background: The species from the genus Garcinia has long been used as traditional medicine for cancer treatment. Objective: To analyze the phytochemical contents and assess the cytotoxic effects of pericarp extracts of Garcinia forbesii King against MCF-7 breast cancer cells and HepG2 liver cancer cells. Materials and Methods: The phytochemical contents were analyzed using the thin-layer chromatography and the cytotoxic activity was assessed using the MTT assay method. Results: Phytochemical screening showed the presence of alkaloids, flavonoids, terpenoids and polyphenols. The cytotoxic activities of n-hexane, DCM and ethyl acetate extracts on MCF-7 cells were shown with IC50 103.605±2.3410 μg/ mL, 397.609±28.0534 μg/mL and 1,518.301±68.6379 μg/mL respectively, while the IC50 on HepG2 cells were 79.798±1.2261 μg/mL, 83.230±4.2557 μg/mL and 671.875±94.3338 μg/mL respectively. Conclusion: The n-hexane, DCM and ethyl acetate extracts from pericarps of G. forbesii King have cytotoxic activities against MCF-7 and HepG2 cancer cells, therefore, it has the potential to be developed as an anticancer.
KW - Anticancer
KW - Cytotoxic
KW - Garcinia forbesii King
KW - HepG2
KW - MCF-7
UR - http://www.scopus.com/inward/record.url?scp=85099377515&partnerID=8YFLogxK
U2 - 10.5530/pj.2021.13.32
DO - 10.5530/pj.2021.13.32
M3 - Article
AN - SCOPUS:85099377515
SN - 0975-3575
VL - 13
SP - 226
EP - 229
JO - Pharmacognosy Journal
JF - Pharmacognosy Journal
IS - 1
ER -
